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GENE：WDFY3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WDFY3
FullNmae WD repeat and FYVE domain containing 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20751
EnsembleID ENSG00000163625
Uniprot Q8IZQ1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WDFY3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WDFY3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WDFY3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
WDFY3 GO:0000421,GO:0005515,GO:0005545,GO:0005635,GO:0005654,GO:0005730,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0016020,GO:0016234,GO:0016605,GO:0030424,GO:0031965,GO:0035973,GO:0035973,GO:0043204,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
WDFY3 hsa:23001 path:hsa04140 Autophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
WDFY3 ATG5 20417604 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
WDFY3 ATG12 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
WDFY3 ATG16L1 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
WDFY3 SQSTM1 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
HTT WDFY3 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
WDFY3 MAP1LC3B 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR WDFY3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 WDFY3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 WDFY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000006FDD4 WDFY3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 WDFY3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E92A8 WDFY3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000018C928 WDFY3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000236310 WDFY3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000079F78 WDFY3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000019F055 WDFY3 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DAXX WDFY3 25348397 N/A physical interaction ComPPI
BAG3 WDFY3 25348397 N/A physical interaction ComPPI
SGTB WDFY3 25348397 N/A physical interaction ComPPI
S100A4 WDFY3 25348397 N/A physical interaction ComPPI
TRAF6 WDFY3 25348397 N/A physical interaction ComPPI
GABARAPL2 WDFY3 24234451 24668264 25348397 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,pull down,physical interaction ComPPI,IntAct
ATXN1 WDFY3 20417604 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
MAP1LC3B WDFY3 18083104 20417604 24234451 24668264 25348397 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,fluorescence microscopy ComPPI,IntAct
DPYSL4 WDFY3 25348397 N/A physical interaction ComPPI
MDFI WDFY3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZBTB44 WDFY3 25348397 N/A physical interaction ComPPI
GRB2 WDFY3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
RHOT2 WDFY3 25348397 N/A physical interaction ComPPI
PIK3R3 WDFY3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
HERC1 WDFY3 25348397 N/A physical interaction ComPPI
PRMT1 WDFY3 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BAG6 WDFY3 25348397 N/A physical interaction ComPPI
TNS2 WDFY3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MYC WDFY3 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SQSTM1 WDFY3 20417604 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ALG13 WDFY3 25348397 N/A physical interaction ComPPI
SUV39H1 WDFY3 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HTT WDFY3 20417604 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
WEE1 WDFY3 25348397 N/A physical interaction ComPPI
GABARAP WDFY3 20562859 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP1LC3A WDFY3 25348397 N/A physical interaction ComPPI
VCAM1 WDFY3 25348397 N/A physical interaction ComPPI
APAF1 WDFY3 25348397 N/A physical interaction ComPPI
SNCA WDFY3 20417604 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PDCD1 WDFY3 25348397 N/A physical interaction ComPPI
EEF2K WDFY3 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HLA-B WDFY3 25348397 N/A physical interaction ComPPI
HLA-E WDFY3 25348397 N/A physical interaction ComPPI
CD79B WDFY3 25348397 N/A physical interaction ComPPI
STAT3 WDFY3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
TERF2IP WDFY3 25348397 N/A physical interaction ComPPI
RAB5C WDFY3 25348397 N/A physical interaction ComPPI
TMEM132A WDFY3 25348397 N/A physical interaction ComPPI
SHMT2 WDFY3 25348397 N/A physical interaction ComPPI
P2RX2 WDFY3 25348397 N/A physical interaction ComPPI
ATG12 WDFY3 25348397 N/A physical interaction ComPPI
ATG16L1 WDFY3 25348397 N/A physical interaction ComPPI
DCAF6 WDFY3 25348397 N/A physical interaction ComPPI
NFE2L1 WDFY3 25348397 N/A physical interaction ComPPI
ICAM1 WDFY3 25348397 N/A physical interaction ComPPI
CEP76 WDFY3 25348397 N/A physical interaction ComPPI
DDX11 WDFY3 25348397 N/A physical interaction ComPPI
GABARAPL1 WDFY3 24234451 24668264 25348397 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,pull down,physical interaction ComPPI,IntAct
TRIM39 WDFY3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEDD1 WDFY3 25348397 N/A physical interaction ComPPI
DMWD WDFY3 25348397 N/A physical interaction ComPPI
PRMT6 WDFY3 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NXF1 WDFY3 25348397 N/A physical interaction ComPPI
ATG5 WDFY3 20417604 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
MOV10 WDFY3 25348397 N/A physical interaction ComPPI
DDX12P WDFY3 25348397 N/A physical interaction ComPPI
FLCN WDFY3 25348397 N/A physical interaction ComPPI
WDR75 WDFY3 25348397 N/A physical interaction ComPPI
MAP1LC3C WDFY3 24234451 24668264 25348397 association,physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,pull down,physical interaction ComPPI,IntAct
RABGAP1L WDFY3 25348397 N/A physical interaction ComPPI
RABGAP1L WDFY3 25348397 N/A physical interaction ComPPI
DYNC2I1 WDFY3 25348397 N/A physical interaction ComPPI
WDFY3 RTEL1 25348397 N/A physical interaction ComPPI
WDFY3 DEF8 25348397 N/A physical interaction ComPPI
WDFY3 SLC2A12 25348397 N/A physical interaction ComPPI
H2BC9 WDFY3 24234451 30021884 physical association cross-linking study IntAct
WDFY3 ATG12 20417604 27898060 stimulant N/A OmniPath
WDFY3 SQSTM1 20168092 20417604 20971078 24128730 27898060 stimulant N/A OmniPath
ATG5 WDFY3 20417604 27898060 N/A N/A OmniPath

Visualization










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