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GENE：PIK3C3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3C3
FullNmae phosphatidylinositol 3-kinase catalytic subunit type 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8974
EnsembleID ENSG00000078142
Uniprot Q8NEB9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3C3 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PIK3C3 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PIK3C3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3C3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PIK3C3 GO:0000045,GO:0000045,GO:0000407,GO:0004672,GO:0005515,GO:0005524,GO:0005737,GO:0005768,GO:0005770,GO:0005777,GO:0005829,GO:0005930,GO:0006497,GO:0006622,GO:0006897,GO:0006914,GO:0007049,GO:0010506,GO:0016020,GO:0016020,GO:0016236,GO:0016236,GO:0016241,GO:0016301,GO:0016303,GO:0016303,GO:0016303,GO:0016303,GO:0016310,GO:0030242,GO:0030496,GO:0030670,GO:0032465,GO:0034271,GO:0034272,GO:0034497,GO:0035032,GO:0035032,GO:0036092,GO:0036092,GO:0042149,GO:0044754,GO:0044829,GO:0045022,GO:0045022,GO:0046854,GO:0048015,GO:0051301,GO:0061912,GO:0061912,GO:0097352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3C3 hsa:5289 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa04136 Autophagy - other - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa04145 Phagosome - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05016 Huntington disease - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05131 Shigellosis - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05132 Salmonella infection - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05152 Tuberculosis - Homo sapiens (human)
PIK3C3 hsa:5289 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BECN1 PIK3C3 17106237 17446862 18612260 19270696 22093031 22166994 22421439 22885520 23030059 23180781 23301705 23377657 23725295 24070470 26192618 27754749 28645028 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
PIK3C3 ATG14 17106237 17446862 18612260 18843052 19050071 22093031 22166994 22421439 22885520 23030059 23180781 23301705 23377657 23725295 24070470 26192618 27754749 28645028 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
UVRAG PIK3C3 16227588 17106237 17446862 17891140 18612260 18843052 19265852 22093031 22166994 22421439 22885520 23030059 23180781 23301705 23377657 23725295 24070470 26192618 27754749 28645028 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
PIK3C3 BECN1 16179260 16390869 17438366 18628207 18843052 19050071 19270696 19713971 23180781 physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB
PIK3C3 UVRAG 18843052 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG14 PIK3C3 18843052 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3C3 PIK3R4 18957027 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3C3 AMBRA1 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
RUBCN PIK3C3 22423967 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PIK3C3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PIK3C3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC PIK3C3 12747840 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PIK3C3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PIK3C3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 PIK3C3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C770D PIK3C3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000023133F PIK3C3 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D PIK3C3 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00001E96DA PIK3C3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000054DF42 PIK3C3 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 PIK3C3 22135298 phosphorylation N/A PhosphoSite
CDK5 PIK3C3 22135298 phosphorylation N/A PhosphoSite
PIK3C3 CHAF1A 25361965 interaction type N/A PTMCode2
CHAF1A PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 AMBRA1 25361965 interaction type N/A PTMCode2
AMBRA1 PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 UVRAG 25361965 interaction type N/A PTMCode2
UVRAG PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 PIK3R4 25361965 interaction type N/A PTMCode2
PIK3R4 PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 BECN1 25361965 interaction type N/A PTMCode2
BECN1 PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 SACM1L 25361965 interaction type N/A PTMCode2
SACM1L PIK3C3 25361965 interaction type N/A PTMCode2
ATG14 PIK3C3 25361965 interaction type N/A PTMCode2
PIK3C3 ATG14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RAB39A PIK3C3 24234451 24349490 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SH3GLB1 PIK3C3 24056303 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAG PIK3C3 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EXOC8 PIK3C3 25348397 N/A physical interaction ComPPI
SLAMF1 PIK3C3 22493499 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SKAP1 PIK3C3 25348397 N/A physical interaction ComPPI
CD5 PIK3C3 25348397 N/A experimental interaction detection,physical interaction ComPPI
NRBF2 PIK3C3 20562859 24234451 24785657 24849286 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
HSP90AA1 PIK3C3 25348397 N/A physical interaction ComPPI
NTRK1 PIK3C3 25348397 N/A physical interaction ComPPI
PITPNA PIK3C3 14525934 25348397 8999962 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RUBCN PIK3C3 20562859 21062745 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
HSPA5 PIK3C3 25348397 N/A physical interaction ComPPI
HSPA1A PIK3C3 25348397 N/A physical interaction ComPPI
HSPA1B PIK3C3 25348397 N/A physical interaction ComPPI
PRMT5 PIK3C3 25348397 N/A physical interaction ComPPI
HNRNPL PIK3C3 25348397 N/A physical interaction ComPPI
RAB5A PIK3C3 25348397 N/A physical interaction ComPPI
KRIT1 PIK3C3 25348397 N/A physical interaction ComPPI
EXOC2 PIK3C3 25348397 N/A physical interaction ComPPI
YWHAQ PIK3C3 25348397 N/A physical interaction ComPPI
RNF2 PIK3C3 25348397 N/A physical interaction ComPPI
TRIM28 PIK3C3 25348397 N/A physical interaction ComPPI
HSPA9 PIK3C3 24234451 24785657 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
USP11 PIK3C3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKN PIK3C3 25348397 N/A physical interaction ComPPI
BECN1 PIK3C3 19050071 20562859 23316280 23332761 23364696 23954414 24034250 24056303 24234451 24472739 24785657 25348397 25490155 25594178 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,electron microscopy,molecular sieving,physical interaction ComPPI,IntAct
PIK3C3 PIK3R4 14525934 20562859 24234451 24785657 24849286 25348397 8999962 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PIK3C3 ATG14 11157979 16421251 18843052 19050071 19270696 20562859 22493499 23262492 23332761 24165940 24234451 24785657 24980960 25348397 25490155 27898060 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,electron microscopy,molecular sieving,pull down,physical interaction,phosphotransferase assay ComPPI,IntAct,OmniPath
PIK3C3 MAP1LC3C 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C3 UVRAG 20562859 22493499 24056303 24234451 24785657 24849286 25348397 25490155 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PIK3C3 CLPTM1L 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C3 MYH9 25348397 N/A physical interaction ComPPI
PIK3C3 DBN1 25348397 N/A physical interaction ComPPI
PIK3C3 HSP90AA2P 25348397 N/A physical interaction ComPPI
PIK3C3 DACT1 25348397 N/A physical interaction ComPPI
PIK3C3 AMBRA1 25348397 N/A physical interaction ComPPI
PIK3C3 JADE2 25348397 N/A physical interaction ComPPI
PIK3C3 USP18 25348397 N/A physical interaction ComPPI
PIK3C3 RUBCNL 25348397 N/A physical interaction ComPPI
PIK3C3 LGALS7 25348397 N/A physical interaction ComPPI
PIK3C3 FBXL20 25348397 N/A physical interaction ComPPI
PIK3C3 BECN2 23954414 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PIK3C3 VMP1 23316280 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3C3 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
KIF1B PIK3C3 25348397 N/A physical interaction ComPPI
MYH1 PIK3C3 25348397 N/A physical interaction ComPPI
PIK3C3 CALM2 12925680 14525934 N/A experimental interaction detection HPRD
PIK3C3 PIK3C3 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
H1-0 PIK3C3 24234451 30021884 physical association cross-linking study IntAct
CDK5 PIK3C3 20513426 27898060 inhibition N/A OmniPath
PIK3C3 PTEN 20212113 27898060 stimulant N/A OmniPath
RUBCN PIK3C3 19270693 19270696 20562859 21062745 22423967 24980960 27898060 inhibition N/A OmniPath
PIK3C3 AKT1 10698680 27898060 stimulant N/A OmniPath
SH3GLB1 PIK3C3 17891140 27898060 stimulant N/A OmniPath
CDK1 PIK3C3 20513426 27898060 inhibition N/A OmniPath
BECN1 PIK3C3 16179260 16390869 17438366 18628207 18843052 19050071 19172397 19270696 19379691 19713971 20562859 20711182 21936852 23315026 23878393 23974797 24472739 24980959 24980960 25825496 25906440 26496610 27898060 stimulant N/A OmniPath
PIK3C3 RPTOR 12150926 27898060 N/A N/A OmniPath
UVRAG PIK3C3 18843052 20562859 24785657 24980960 27898060 stimulant N/A OmniPath
PIK3R4 PIK3C3 11689570 18957027 20562859 21575909 24165940 26344197 27898060 8387919 8999962 stimulant N/A OmniPath

Visualization










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