GENE：MTM1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MTM1 |
| FullNmae | myotubularin 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7448 |
| EnsembleID | ENSG00000171100 |
| Uniprot | Q13496 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MTM1 | lysosomal_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTM1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTM1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTM1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTM1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MTM1 | GO:0000045,GO:0001726,GO:0004438,GO:0004438,GO:0004438,GO:0004721,GO:0005515,GO:0005737,GO:0005737,GO:0005770,GO:0005829,GO:0005829,GO:0005886,GO:0006470,GO:0006661,GO:0008333,GO:0015031,GO:0016020,GO:0019215,GO:0030175,GO:0031674,GO:0031929,GO:0032007,GO:0032435,GO:0035091,GO:0043161,GO:0043491,GO:0044088,GO:0045109,GO:0046716,GO:0046856,GO:0046856,GO:0048311,GO:0048311,GO:0048630,GO:0048633,GO:0051898,GO:0052629,GO:0052629,GO:0052629,GO:0070584,GO:0070584,GO:1902902 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MTM1 | hsa:4534 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| MTM1 | hsa:4534 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| MTM1 | hsa:4534 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | MTM1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MTM1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MTM1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | MTM1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | MTM1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DES | MTM1 | 21135508 24234451 25348397 27898060 | colocalization,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation,cosedimentation in solution,far western blotting,filter binding,pull down,confocal microscopy | ComPPI,IntAct,OmniPath |
| CIAO1 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| KRT5 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| KRT2 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| KBTBD7 | MTM1 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SAMM50 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| ILK | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| SNX6 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| SNX17 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| STIP1 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| TARBP2 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| EXOC4 | MTM1 | 24234451 25348397 26760201 | physical association | pull down,physical interaction | ComPPI,IntAct |
| BIN1 | MTM1 | 23917616 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct,OmniPath |
| CUL4A | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| IMMT | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| RCN1 | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| KMT2A | MTM1 | 25348397 | N/A | physical interaction | ComPPI |
| MTM1 | HLA-C | 25348397 | N/A | physical interaction | ComPPI |
| MTM1 | NDUFA9 | 25348397 | N/A | physical interaction | ComPPI |
| MTM1 | OXA1L | 25348397 | N/A | physical interaction | ComPPI |
| MTM1 | STOML2 | 25348397 | N/A | physical interaction | ComPPI |
| MTM1 | SCO2 | 25348397 | N/A | physical interaction | ComPPI |
| MTM1 | TUBA3C | 25348397 | N/A | physical interaction | ComPPI |
| CALU | MTM1 | 25348397 | N/A | physical interaction | ComPPI |