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GENE：MET

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MET
FullNmae MET proto-oncogene, receptor tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7029
EnsembleID ENSG00000105976
Uniprot P08581

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MET pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MET necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MET mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MET autophagy 35061934 We further found that FOXP2 inhibited MET Proto-Oncogene (MET), which was the initiating factor that regulated the classic AKT/mTOR pathway of autophagy. retulator signature
MET autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MET GO:0001886,GO:0001889,GO:0004713,GO:0004713,GO:0005008,GO:0005515,GO:0005524,GO:0005576,GO:0005886,GO:0006909,GO:0007165,GO:0007166,GO:0007169,GO:0007275,GO:0007399,GO:0009925,GO:0009925,GO:0009986,GO:0010507,GO:0016020,GO:0016310,GO:0016477,GO:0017154,GO:0019903,GO:0030182,GO:0031016,GO:0031116,GO:0033674,GO:0035024,GO:0042802,GO:0043235,GO:0045944,GO:0048012,GO:0048754,GO:0050918,GO:0051497,GO:0061436,GO:0070495,GO:0071526,GO:0140677,GO:1901299,GO:1905098,GO:2001028

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MET hsa:4233 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
MET hsa:4233 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MET hsa:4233 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
MET hsa:4233 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
MET hsa:4233 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
MET hsa:4233 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
MET hsa:4233 path:hsa04360 Axon guidance - Homo sapiens (human)
MET hsa:4233 path:hsa04510 Focal adhesion - Homo sapiens (human)
MET hsa:4233 path:hsa04520 Adherens junction - Homo sapiens (human)
MET hsa:4233 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
MET hsa:4233 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
MET hsa:4233 path:hsa05144 Malaria - Homo sapiens (human)
MET hsa:4233 path:hsa05200 Pathways in cancer - Homo sapiens (human)
MET hsa:4233 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
MET hsa:4233 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
MET hsa:4233 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
MET hsa:4233 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
MET hsa:4233 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
MET hsa:4233 path:hsa05218 Melanoma - Homo sapiens (human)
MET hsa:4233 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
MET hsa:4233 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
MET hsa:4233 path:hsa05226 Gastric cancer - Homo sapiens (human)
MET hsa:4233 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MET CDH1 16909210 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation InnateDB
CTNNB1 MET 16909210 23180781 physical association anti tag coimmunoprecipitation InnateDB
MET FOXC2 23180781 25381815 physical association anti tag coimmunoprecipitation InnateDB
HGF MET 23331499 8380735 stimulation N/A SignaLink
CBL MET 11894096 15123609 16397241 18273061 19450681 23331499 stimulation N/A SignaLink
MET GLMN 11571281 23331499 stimulation N/A SignaLink
MET GRAP 23331499 8662889 stimulation N/A SignaLink
MET RANBP9 12147692 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GAB1 MET 20005715 interaction type N/A PSP
GRB2 MET 20005715 interaction type N/A PSP
HGS MET 20005715 interaction type N/A PSP
PIK3R1 MET 20005715 interaction type N/A PSP
SHC1 MET 20005715 interaction type N/A PSP
YWHAZ MET 20005715 interaction type N/A PSP,SignaLink
HGS MET 18988627 20005715 8380735 N/A N/A SignaLink
GRB2 MET 20005715 21071413 8662889 9660480 N/A N/A SignaLink
GAB1 MET 20005715 20005715 N/A N/A SignaLink
PIK3R1 MET 20005715 20005715 N/A N/A SignaLink
SHC1 MET 18988627 20005715 20005715 21071413 7731718 9660480 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MET 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 MET 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A MET 16099863 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC MET 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MET 19151767 19648825 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 MET 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MET 17371876 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MET 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP2 MET 21832174 trascriptional regulation,stimulation inferred by curator TFlink
PAX3 MET 8633043 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 MET 19139719 24628993 trascriptional regulation,stimulation inferred by curator TFlink
PAX6 MET 19651775 trascriptional regulation,stimulation inferred by curator TFlink
SMAD7 MET 15339794 trascriptional regulation,stimulation inferred by curator TFlink
SP1 MET 11910354 21831840 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 MET 11910354 21831840 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MET 21831840 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 MET N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN MET N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MET N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 MET N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 MET N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A MET N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B MET N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032BD73 MET 20505319 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 MET N/A rna interference,inhibition experimental interaction detection miRSponge
URS000034B6F5 MET 19620785 19710019 20388878 \N rna interference,inhibition western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000183BED MET 19490101 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000001EB3 MET 23552883 23553486 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000007FBA MET 21225860 rna interference,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 MET 18834857 19006648 19029026 19461653 19773441 20309880 22159222 22457788 \N rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000027352D MET 19461653 20924086 22419847 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002C7B2B MET 19461653 20198305 20924086 22419847 \N rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001F5B39 MET 21418558 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00003758F0 MET 21418558 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000315338 MET 21706050 22743998 23418453 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr miRDeathDB,TarBase
URS000000C73C MET 21868754 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS000034B6F5 MET 18927107 19620785 19710019 20388878 25416803 26186594 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00002C7B2B MET 19461653 20198305 20924086 22419847 23922103 25416803 26795575 mrna cleavage,inhibition array technology,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000027352D MET 19461653 20924086 22419847 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 MET 18834857 19006648 19029026 19461653 19773441 20309880 21240262 22159222 22457788 23970470 24983493 25416803 26238271 26313360 27364974 27513895 28250026 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000183BED MET 19490101 25405368 25416803 28077801 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000065D58 MET 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000007FBA MET 21692045 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001F5B39 MET 21418558 23734217 25416803 26471185 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003758F0 MET 21418558 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000032BD73 MET 20505319 24391788 25416803 mrna cleavage,inhibition experimental interaction detection,western blot TarBase
URS0000001EB3 MET 22948084 23552883 23553486 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000032FC1A MET 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD MET 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F MET 23650389 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E3523 MET 23151846 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002233F4 MET 22750473 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 MET 24013226 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00002198F3 MET 25416803 26141986 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000081E1F MET 23820886 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E92A8 MET 25416803 25927670 25961751 26250785 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000024DFCE MET 25416803 26844702 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000023BE29 MET 25416803 26497851 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 MET 25405368 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000568FF8 MET 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000048BA36 MET 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000075A611 MET 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002E1509 MET 25416803 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD MET 22135298 phosphorylation N/A PhosphoSite
ABL1 MET 22135298 phosphorylation N/A PhosphoSite
BMX MET 22135298 phosphorylation N/A PhosphoSite
MST1R MET 22135298 phosphorylation N/A PhosphoSite
MET PARP1 22135298 phosphorylation N/A PhosphoSite
MET SHC1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MET MET 22135298 phosphorylation N/A PhosphoSite
MET MST1R 22135298 phosphorylation N/A PhosphoSite
MET PTK2 22135298 phosphorylation N/A PhosphoSite
PRKG2 MET 22135298 phosphorylation N/A PhosphoSite
FER MET 22135298 phosphorylation N/A PhosphoSite
PRKCE MET 22135298 phosphorylation N/A PhosphoSite
PRKCA MET 22135298 phosphorylation N/A PhosphoSite
STAT3 MET 25361965 interaction type N/A PTMCode2
MET STAT3 25361965 interaction type N/A PTMCode2
CBL MET 25361965 interaction type N/A PTMCode2
MET CBL 25361965 interaction type N/A PTMCode2
MET SPSB1 25361965 interaction type N/A PTMCode2
SPSB1 MET 25361965 interaction type N/A PTMCode2
MET HGS 25361965 interaction type N/A PTMCode2
HGS MET 25361965 interaction type N/A PTMCode2
MET GRB2 25361965 interaction type N/A PTMCode2
GRB2 MET 25361965 interaction type N/A PTMCode2
MET CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 MET 25361965 interaction type N/A PTMCode2
MET SRC 25361965 interaction type N/A PTMCode2
SRC MET 25361965 interaction type N/A PTMCode2
MET GLMN 25361965 interaction type N/A PTMCode2
GLMN MET 25361965 interaction type N/A PTMCode2
MET PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 MET 25361965 interaction type N/A PTMCode2
MET SH3KBP1 25361965 interaction type N/A PTMCode2
SH3KBP1 MET 25361965 interaction type N/A PTMCode2
MET SOS1 25361965 interaction type N/A PTMCode2
SOS1 MET 25361965 interaction type N/A PTMCode2
MET MUC20 25361965 interaction type N/A PTMCode2
MUC20 MET 25361965 interaction type N/A PTMCode2
MET PTPRJ 25361965 interaction type N/A PTMCode2
PTPRJ MET 25361965 interaction type N/A PTMCode2
SHC1 MET 25361965 interaction type N/A PTMCode2
RANBP10 MET 25361965 interaction type N/A PTMCode2
MET RANBP10 25361965 interaction type N/A PTMCode2
CASP3 MET 25361965 interaction type N/A PTMCode2
MET CASP3 25361965 interaction type N/A PTMCode2
GAB1 MET 25361965 interaction type N/A PTMCode2
MET GAB1 25361965 interaction type N/A PTMCode2
ITGB4 MET 25361965 interaction type N/A PTMCode2
MET ITGB4 25361965 interaction type N/A PTMCode2
INPPL1 MET 25361965 interaction type N/A PTMCode2
MET INPPL1 25361965 interaction type N/A PTMCode2
EGFR MET 25361965 interaction type N/A PTMCode2
MET EGFR 25361965 interaction type N/A PTMCode2
CDH1 MET 25361965 interaction type N/A PTMCode2
MET CDH1 25361965 interaction type N/A PTMCode2
RANBP9 MET 25361965 interaction type N/A PTMCode2
MET RANBP9 25361965 interaction type N/A PTMCode2
BAG1 MET 25361965 interaction type N/A PTMCode2
MET BAG1 25361965 interaction type N/A PTMCode2
PIK3R1 MET 25361965 interaction type N/A PTMCode2
MET PIK3R1 25361965 interaction type N/A PTMCode2
HGF MET 25361965 interaction type N/A PTMCode2
MET HGF 25361965 interaction type N/A PTMCode2
GAB2 MET 25361965 interaction type N/A PTMCode2
MET GAB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SPSB3 MET 25348397 N/A physical interaction ComPPI
PIK3R2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SOCS3 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
YES1 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PCBD2 MET 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SH3KBP1 MET 25348397 N/A physical interaction ComPPI
PCBP1 MET 25348397 N/A physical interaction ComPPI
HSP90AB1 MET 25348397 N/A physical interaction ComPPI
CRK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy,physical interaction ComPPI,IntAct
STAP1 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
CD44 MET 22897854 24234451 25348397 physical association cross-linking study ComPPI,IntAct
GRB7 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
CBL MET 11894096 14525934 18273061 21163258 24234451 25241761 25348397 ubiquitination reaction,physical association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,mass spectrometry studies of complexes,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
VAV1 MET 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
BTK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SYK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SHB MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
TEC MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SH3BP2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SOCS1 MET 24234451 24728074 25348397 25728680 27898060 N/A fluorescence polarization spectroscopy,physical interaction ComPPI,IntAct,OmniPath
VAV2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
LYN MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R1 MET 14525934 24234451 24728074 25348397 7513258 N/A experimental interaction detection,fluorescence polarization spectroscopy,in vitro ComPPI,HPRD,IntAct
PTPN11 MET 14525934 18579758 24234451 24728074 25348397 8662733 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,in vivo ComPPI,HPRD,IntAct
SRC MET 14525934 20624308 24034250 24234451 24728074 25348397 9837958 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vivo ComPPI,HPRD,IntAct
MATK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PTPRO MET 19167335 24234451 25348397 28330616 dephosphorylation reaction,association pull down,phosphatase assay ComPPI,IntAct
SH2B3 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
LCK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SH2B2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
INPP5D MET 14525934 15735664 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
VAV3 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
KDR MET 22789536 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PLCG2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SHC1 MET 14525934 24234451 24728074 25348397 7731718 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vivo ComPPI,HPRD,IntAct
SOS1 MET 25348397 N/A physical interaction ComPPI
NCK1 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
CASP3 MET 14525934 15542841 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
GAB2 MET 25348397 N/A physical interaction ComPPI
CBLC MET 25348397 N/A physical interaction ComPPI
GRB2 MET 11439336 14525934 15546961 25348397 7511210 8662889 9660480 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ZAP70 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
ITK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BLK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
INPPL1 MET 14525934 15735664 24234451 24728074 25348397 N/A two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SLA2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
YWHAZ MET 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FES MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
HGS MET 14525934 25348397 8380735 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GAB1 MET 10734310 10913131 10995442 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PIK3R3 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
HSP90AA1 MET 25348397 N/A physical interaction ComPPI
CDH1 MET 25348397 N/A physical interaction ComPPI
PTPN1 MET 16537444 18579758 22789536 24234451 25348397 dephosphorylation reaction,physical association anti bait coimmunoprecipitation,cross-linking study,phosphatase assay ComPPI,IntAct
BAG1 MET 25348397 N/A in vivo ComPPI
GRB14 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SNX2 MET 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TNS2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SOCS2 MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PTPRB MET 14525934 16101282 24234451 25348397 dephosphorylation reaction experimental interaction detection,phosphatase assay,in vitro ComPPI,HPRD,IntAct
DNAJA3 MET 14525934 15546961 21242965 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,pull down,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
PTPRG MET 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
HGFAC MET 25348397 27898060 9537587 N/A experimental interaction detection,physical interaction ComPPI,OmniPath
PTPN12 MET 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
DAPK3 MET 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PKM MET 25348397 N/A protein kinase assay ComPPI
RANBP9 MET 12147692 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MET SNAPIN 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MET SMC1A 14525934 15546961 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MET STAT3 14525934 25348397 9440692 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MET CNR1 11894096 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MET EGFR 10722725 14525934 20624308 23866081 24189400 24234451 25348397 26551075 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,phosphorylation reaction,physical interaction,protein kinase assay,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MET CTNNB1 11929826 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MET FAS 14525934 15911745 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MET ITGB4 11733063 14525934 14602071 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MET SPSB1 14525934 15713673 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MET CTTN 11439336 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MET HGF 14525934 15167892 16537482 1655405 17804794 17981115 1846706 18495663 24234451 25348397 physical association cross-linking study,experimental interaction detection,fluorescent resonance energy transfer,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,x ray scattering,amplified luminescent proximity homogeneous assay ComPPI,HPRD,IntAct
MET PLXNB1 12198496 14525934 15184888 22404908 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
MET GLMN 11571281 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MET RANBP10 14525934 14684163 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MET MUC20 25348397 N/A two hybrid,in vitro,in vivo ComPPI
MET LRIG1 17178829 24828152 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MET DCN 25348397 N/A physical interaction ComPPI
MET SPSB2 25348397 N/A physical interaction ComPPI
MET SPSB4 25348397 N/A physical interaction ComPPI
MET STUB1 25348397 N/A physical interaction ComPPI
MET HSPA4 25348397 N/A physical interaction ComPPI
MET HSP90AA2P 25348397 N/A physical interaction ComPPI
MET GGA3 21664574 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MET FBXO6 25348397 N/A physical interaction ComPPI
MET CEACAM21 25348397 N/A physical interaction ComPPI
MET LGALS9 25348397 N/A physical interaction ComPPI
MET ERBB3 24234451 25326665 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MET SCGB1D1 25348397 N/A physical interaction ComPPI
MET PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
MET PTPRK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
MET PTPRJ 12370829 12475979 14525934 19167335 24234451 25348397 dephosphorylation reaction,physical association affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,pull down,biochemical,phosphatase assay ComPPI,HPRD,IntAct
MET PTPN3 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
MET PLXNB2 15184888 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
MET PLXNB3 15184888 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
MET PASK 21418524 24234451 25348397 phosphorylation reaction peptide array ComPPI,IntAct
MET MUC1 22962849 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
MET RASA1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SOCS6 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SHC4 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SH2D1B 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SHD 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SHC2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SH2D3C 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET TNS3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SH2D2A 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SH2D1A 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET PLCG1 14525934 24234451 24728074 25348397 7513258 8662733 N/A experimental interaction detection,fluorescence polarization spectroscopy ComPPI,HPRD,IntAct
MET SOCS5 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET TNS1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET FGR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SHC3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET HCK 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET PTK6 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET TXK 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET ABL2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET HSH2D 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET SH2B1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET TNS4 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET BCAR3 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MET LAPTM4B 24234451 25348397 25594178 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
MET SCRIB 24234451 24550280 25348397 physical association phage display ComPPI,IntAct
MET LAMP1 24234451 25348397 29568061 association pull down ComPPI,IntAct
GNG12 MET 25348397 N/A physical interaction ComPPI
MET MET 14525934 16537482 1655405 1655790 17192257 20624990 24234451 physical association cross-linking study,experimental interaction detection,amplified luminescent proximity homogeneous assay HPRD,IntAct
PRKCA MET 15075332 27898060 8294430 inhibition N/A OmniPath
PTPN1 MET 16537444 18579758 18819921 22789536 27898060 inhibition N/A OmniPath
PRKCE MET 15075332 27898060 inhibition N/A OmniPath
PRKCD MET 15075332 27898060 N/A N/A OmniPath
MET ITGB4 11733063 14602071 27898060 N/A N/A OmniPath
PTPRF MET 16415345 27898060 N/A N/A OmniPath
PTPN2 MET 18819921 27898060 inhibition N/A OmniPath
MET PTK2 11909938 14739293 15026417 15561106 15707572 16782899 17317726 19815712 20658524 20802513 20802517 27898060 stimulant N/A OmniPath
MET GAB1 10734310 10753869 10871282 10913131 10978177 10995442 14685170 16497976 17016520 17389395 18669648 19901323 20068231 27898060 9242692 stimulant N/A OmniPath
TP53 MET 18431400 27898060 stimulant N/A OmniPath
MET SHC1 11687594 11884620 14685170 14990987 15688026 15708852 18687633 19690143 24728074 27898060 7731718 8084588 8939605 8947042 9083103 stimulant N/A OmniPath
CBL MET 11894096 15123609 16397241 18273061 19433454 19450681 21163258 21222362 25241761 27898060 inhibition,stimulant N/A OmniPath
HGF MET 14685170 15167892 16537482 1655405 17145710 17804794 17981115 1846706 18495663 19433454 20624990 27898060 8380735 stimulant N/A OmniPath
MET RANBP9 12147692 27898060 stimulant N/A OmniPath
DCN MET 10942781 19433454 27898060 N/A N/A OmniPath
MET MST1R 10490849 10506185 10871856 11064459 11741535 12475979 12766170 16782899 18836480 20016000 20726546 21777671 27898060 7513258 7687741 7731718 7838524 7961992 8547236 8906793 9242692 9391119 9444958 9826708 N/A N/A OmniPath
MST1R MET 10490849 10506185 10871856 11064459 11741535 12475979 12766170 16782899 18836480 20016000 20726546 21777671 27898060 7513258 7687741 7731718 7838524 7961992 8547236 8906793 9242692 9391119 9444958 9826708 stimulant N/A OmniPath
PTPRB MET 16101282 21454675 27898060 inhibition N/A OmniPath
MET GLMN 11571281 27898060 inhibition,stimulant N/A OmniPath
MET GRAP 27898060 8662889 stimulant N/A OmniPath
MET MAP4K1 11487585 15743830 27898060 N/A N/A OmniPath
MET PLXNB3 15184888 15218527 27898060 N/A N/A OmniPath
PTPRJ MET 12370829 12475979 19167335 27898060 inhibition N/A OmniPath
MET SPSB1 15713673 27898060 N/A N/A OmniPath

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