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GENE：GBA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GBA
FullNmae glucosylceramidase beta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4177
EnsembleID ENSG00000177628
Uniprot P04062

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GBA lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
GBA lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GBA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GBA autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GBA autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GBA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GBA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GBA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 GBA 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 GBA 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GBA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 GBA 9272862 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GBA 8642300 trascriptional regulation,stimulation inferred by curator TFlink
ETS2 GBA N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN GBA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002B2B5C GBA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000013ABA3 GBA 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RAB14 GBA 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CBL GBA 21098288 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AA1 GBA 25348397 N/A physical interaction ComPPI
NTRK1 GBA 25348397 N/A physical interaction ComPPI
CANX GBA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90B1 GBA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA PSAP 14525934 25348397 27898060 7613473 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
GBA NEDD4 25348397 N/A physical interaction ComPPI
GBA HSPA4 25348397 N/A physical interaction ComPPI
GBA PRKN 25348397 N/A physical interaction ComPPI
GBA FBXO6 25348397 N/A physical interaction ComPPI
GBA SNCA 21653695 23266198 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GBA ITCH 25348397 N/A physical interaction ComPPI
GBA PCBP2 25348397 N/A physical interaction ComPPI
GBA DHCR24 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA FMR1 25348397 N/A physical interaction ComPPI
GBA HSPD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA RPS6KA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA CCT3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA TOP3B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA SCAMP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA PATJ 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA HYOU1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA CCT8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA ZMYND11 25348397 N/A physical interaction ComPPI
GBA MTREX 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA BMP2K 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA ZCCHC8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBA ZFP91 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
GBA COMT 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GBA RAB21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GBA RDH11 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GBA A2M 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
GBA RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
GBA MAGEA11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCP1 GBA 21098288 22160715 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RAB27B GBA 25348397 N/A physical interaction ComPPI
IMP3 GBA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF20 GBA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct

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