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GENE：LRSAM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRSAM1
FullNmae leucine rich repeat and sterile alpha motif containing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25135
EnsembleID ENSG00000148356
Uniprot Q6UWE0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRSAM1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LRSAM1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LRSAM1 GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006914,GO:0016020,GO:0030163,GO:0045806,GO:0046755,GO:0046872,GO:0051865,GO:0061630,GO:0070086,GO:1904417,GO:2000786

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 LRSAM1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 LRSAM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 LRSAM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 LRSAM1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 LRSAM1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LRSAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRSAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LRSAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LRSAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 LRSAM1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000239117 LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0874 LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 LRSAM1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HSPBP1 LRSAM1 25348397 N/A physical interaction ComPPI
RXRG LRSAM1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GABARAPL2 LRSAM1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATXN1 LRSAM1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DR1 LRSAM1 25348397 N/A physical interaction ComPPI
UBE2D1 LRSAM1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSP90AB1 LRSAM1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
ERO1A LRSAM1 25348397 N/A physical interaction ComPPI
UBE2D4 LRSAM1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RNF111 LRSAM1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D2 LRSAM1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSP90AA1 LRSAM1 25348397 N/A physical interaction ComPPI
UBE2N LRSAM1 19549727 19690564 24234451 25260751 25348397 ubiquitination reaction,physical association two hybrid,physical interaction,two hybrid array,ubiquitinase assay ComPPI,IntAct
DBNL LRSAM1 25348397 N/A physical interaction ComPPI
DDX5 LRSAM1 25348397 N/A physical interaction ComPPI
GSK3A LRSAM1 14525934 14635195 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MDM4 LRSAM1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
KLC1 LRSAM1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EGFR LRSAM1 25348397 N/A physical interaction ComPPI
UBE2K LRSAM1 25348397 N/A physical interaction ComPPI
XAF1 LRSAM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLIN3 LRSAM1 25348397 N/A physical interaction ComPPI
AP3B1 LRSAM1 25348397 N/A physical interaction ComPPI
UBE2D3 LRSAM1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBA1 LRSAM1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
GRIK5 LRSAM1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GOPC LRSAM1 25348397 N/A physical interaction ComPPI
TERF1 LRSAM1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
UBE2H LRSAM1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRSAM1 MYL2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LRSAM1 TNFRSF10C 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LRSAM1 NINL 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LRSAM1 UBE2J1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRSAM1 UBE2E1 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRSAM1 UBE2W 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LRSAM1 ATXN7 21078624 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LRSAM1 YTHDF1 25348397 N/A physical interaction ComPPI
LRSAM1 USP2 25348397 N/A physical interaction ComPPI
LRSAM1 USP21 25348397 N/A physical interaction ComPPI
LRSAM1 HSF1 25348397 N/A physical interaction ComPPI
LRSAM1 CBS 25348397 N/A physical interaction ComPPI
LRSAM1 MTMR2 25348397 N/A physical interaction ComPPI
LRSAM1 PPME1 25348397 N/A physical interaction ComPPI
LRSAM1 UBE3A 25348397 N/A physical interaction ComPPI
LRSAM1 UTP6 25348397 N/A physical interaction ComPPI
LRSAM1 UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
LRSAM1 CCDC6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CTPS2 LRSAM1 25348397 N/A physical interaction ComPPI

Visualization










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