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GENE：CTSA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTSA
FullNmae cathepsin A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9251
EnsembleID ENSG00000064601
Uniprot P10619

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTSA lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CTSA lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CTSA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTSA autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTSA autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CTSA GO:0004180,GO:0004185,GO:0004185,GO:0005576,GO:0005764,GO:0005783,GO:0006508,GO:0006886,GO:0008047,GO:0016020,GO:0031647,GO:0035578,GO:0043202,GO:0043231,GO:0070062,GO:0098575,GO:1904714,GO:1904715

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTSA hsa:5476 path:hsa04142 Lysosome - Homo sapiens (human)
CTSA hsa:5476 path:hsa04614 Renin-angiotensin system - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRDM14 CTSA 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA CTSA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CTSA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CTSA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CTSA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CTSA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CTSA 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000002103A CTSA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F6E49 CTSA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000315338 CTSA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F CTSA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA CTSA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 CTSA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004F2EB0 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029D9F1 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000170CF4 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AB32B CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A939F CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007A060 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A6D0C CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AB14 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000512C88 CTSA 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CTSA NEU1 25361965 interaction type N/A PTMCode2
NEU1 CTSA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 CTSA 25348397 N/A physical interaction ComPPI
VIM CTSA 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
LMNA CTSA 25348397 N/A physical interaction ComPPI
GABARAPL2 CTSA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CTNNBIP1 CTSA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOC CTSA 25348397 N/A physical interaction ComPPI
RHOA CTSA 25348397 N/A physical interaction ComPPI
VAPA CTSA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSD CTSA 25348397 N/A physical interaction ComPPI
PLAUR CTSA 25348397 N/A physical interaction ComPPI
NAXE CTSA 25348397 N/A physical interaction ComPPI
CASP7 CTSA 25348397 N/A physical interaction ComPPI
DNAJB2 CTSA 25348397 N/A physical interaction ComPPI
RAB2A CTSA 25348397 N/A physical interaction ComPPI
ABCE1 CTSA 25348397 N/A physical interaction ComPPI
SUMO2 CTSA 25348397 N/A physical interaction ComPPI
CDK2 CTSA 25348397 N/A physical interaction ComPPI
GABARAP CTSA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CTSA GLB1 14525934 24234451 25348397 9501080 physical association experimental interaction detection,physical interaction,in vitro,inference by socio-affinity scoring ComPPI,HPRD,IntAct
CTSA LAMP2 12505983 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSA NEU1 14525934 25348397 3102233 3922758 9501080 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CTSA OAT 25348397 N/A physical interaction ComPPI
CTSA FBXO6 25348397 N/A physical interaction ComPPI
CTSA ABHD14A 25348397 N/A physical interaction ComPPI
CTSA BZW2 25348397 N/A physical interaction ComPPI
CTSA FTO 25348397 N/A physical interaction ComPPI
CTSA MVD 25348397 N/A physical interaction ComPPI
CTSA NAMPT 25348397 N/A physical interaction ComPPI
CTSA PEPD 25348397 N/A physical interaction ComPPI
CTSA MEPCE 25348397 N/A physical interaction ComPPI
CTSA NECTIN4 25348397 N/A physical interaction ComPPI
CTSA TIMM9 25348397 N/A physical interaction ComPPI
CTSA TRNT1 25348397 N/A physical interaction ComPPI
CTSA KLHDC9 25348397 N/A physical interaction ComPPI
CTSA SFXN5 25348397 N/A physical interaction ComPPI
CTSA RORC 25348397 N/A physical interaction ComPPI
CTSA YPEL5 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CTSA GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ASS1 CTSA 25348397 N/A physical interaction ComPPI
GINS2 CTSA 25348397 N/A physical interaction ComPPI
CTSA CTSA 14525934 3136930 8591035 N/A experimental interaction detection HPRD
LTB4R2 CTSA 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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