GENE：HTR2B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HTR2B |
| FullNmae | 5-hydroxytryptamine receptor 2B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5294 |
| EnsembleID | ENSG00000135914 |
| Uniprot | P41595 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HTR2B | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HTR2B | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HTR2B | GO:0001587,GO:0001755,GO:0001819,GO:0001819,GO:0001938,GO:0001965,GO:0002031,GO:0003007,GO:0003300,GO:0004993,GO:0004993,GO:0004993,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0005886,GO:0006874,GO:0007186,GO:0007187,GO:0007200,GO:0007202,GO:0007205,GO:0007208,GO:0007268,GO:0007610,GO:0008284,GO:0008284,GO:0009410,GO:0010513,GO:0014033,GO:0014827,GO:0016310,GO:0019722,GO:0019934,GO:0030425,GO:0030594,GO:0042310,GO:0043066,GO:0043123,GO:0043406,GO:0043491,GO:0045202,GO:0048598,GO:0050795,GO:0051000,GO:0051209,GO:0051209,GO:0051209,GO:0051378,GO:0051781,GO:0070371,GO:0070374,GO:0070528,GO:0071502,GO:0098664,GO:0098664,GO:0098666,GO:0098666 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| HTR2B | hsa:3357 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| HTR2B | hsa:3357 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| HTR2B | hsa:3357 | path:hsa04540 | Gap junction - Homo sapiens (human) |
| HTR2B | hsa:3357 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| HTR2B | hsa:3357 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AGTR1 | HTR2B | 25348397 | N/A | physical interaction | ComPPI |
| MPDZ | HTR2B | 11150294 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| GNAQ | HTR2B | 11916537 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SNTA1 | HTR2B | 25348397 | N/A | physical interaction | ComPPI |
| GNA11 | HTR2B | 11916537 14525934 25348397 8621713 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| HTR2B | LNX1 | 25348397 | N/A | physical interaction | ComPPI |
| HTR2B | BNIP3 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | ATP1B1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | ABCA3 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | G6PC3 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | CHPT1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | CBR1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | BNIP3L | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | PLLP | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | NIPA2 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | PPP1R3F | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | METRN | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | MATR3 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | KIF19 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | INSIG1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | NAT14 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | HDGFL2 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | OAZ1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | HAT1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | TRAM1L1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | RAE1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | SLC44A2 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | SLC37A1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | SLC31A2 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| HTR2B | OAT | 24234451 30021884 | physical association | cross-linking study | IntAct |
| TPH1 | HTR2B | 10953292 27898060 | stimulant | N/A | OmniPath |