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GENE：VPS35

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VPS35
FullNmae VPS35 retromer complex component
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13487
EnsembleID ENSG00000069329
Uniprot Q96QK1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VPS35 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
VPS35 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
VPS35 GO:0005515,GO:0005739,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0005829,GO:0006886,GO:0007040,GO:0010008,GO:0010628,GO:0010629,GO:0010821,GO:0014069,GO:0016055,GO:0016241,GO:0030904,GO:0030904,GO:0030904,GO:0030904,GO:0030906,GO:0030906,GO:0031647,GO:0031648,GO:0031748,GO:0032456,GO:0032463,GO:0036010,GO:0042147,GO:0042147,GO:0042147,GO:0043005,GO:0043025,GO:0043653,GO:0045056,GO:0045732,GO:0048471,GO:0050728,GO:0050804,GO:0050882,GO:0051246,GO:0051246,GO:0060161,GO:0061357,GO:0070062,GO:0090128,GO:0090141,GO:0090263,GO:0090326,GO:0097422,GO:0098691,GO:0098793,GO:0098887,GO:0098978,GO:0099003,GO:0099073,GO:0099074,GO:0099639,GO:0150052,GO:1902823,GO:1902950,GO:1903181,GO:1903828,GO:1904377,GO:1904377,GO:1905166,GO:1905606,GO:2000331

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VPS35 hsa:55737 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
VPS35 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZBP1 VPS35 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 VPS35 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 VPS35 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF VPS35 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272039 VPS35 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001B341F VPS35 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000148B91 VPS35 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C VPS35 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000014F13C VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C7662 VPS35 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 VPS35 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004A6E26 VPS35 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000077AED VPS35 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 VPS35 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AIMP2 VPS35 25348397 N/A physical interaction ComPPI
LCA5 VPS35 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 VPS35 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 VPS35 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ZNF512B VPS35 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KEAP1 VPS35 25348397 N/A physical interaction ComPPI
H3-3A VPS35 25348397 N/A physical interaction ComPPI
VPS35 SNX1 11102511 14525934 24234451 25348397 physical association experimental interaction detection,molecular sieving,physical interaction,in vivo,lexa b52 complementation ComPPI,HPRD,IntAct
VPS35 VPS29 11102511 14525934 17696874 17891154 17892535 22593205 22863883 22939629 24234451 24344282 24747528 25348397 25416956 26344197 27898060 9700157 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,two hybrid array,in vitro,lexa b52 complementation,two hybrid prey pooling approach,thermal shift binding,validated two hybrid,two hybrid ComPPI,HPRD,IntAct,OmniPath
VPS35 VPS26B 14525934 16190980 22939629 24234451 25348397 26186194 26344197 26496610 27898060 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
VPS35 MTNR1B 14525934 17215244 24234451 25348397 26514267 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
VPS35 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 USP43 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 USP32 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 WASHC2C 25348397 N/A physical interaction ComPPI
VPS35 RYK 25348397 N/A physical interaction ComPPI
VPS35 ZBP1 25348397 N/A physical interaction ComPPI
VPS35 IRF4 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 ELAVL1 25348397 N/A physical interaction ComPPI
VPS35 ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 MUL1 25348397 N/A physical interaction ComPPI
VPS35 TBC1D5 20923837 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 CDK2 25348397 N/A physical interaction ComPPI
VPS35 ANKFY1 22284051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS35 SNX3 22673115 24344282 25348397 27898060 N/A physical interaction ComPPI,OmniPath
VPS35 HGS 25348397 N/A physical interaction ComPPI
VPS35 APP 25348397 N/A physical interaction ComPPI
VPS35 VPS26A 11102511 15078903 16732284 17891154 22863883 22939629 24234451 24344282 24747528 25348397 26186194 26344197 26496610 27898060 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,transmission electron microscopy,molecular sieving,pull down,physical interaction,two hybrid array,confocal microscopy,lexa b52 complementation,two hybrid prey pooling approach,thermal shift binding ComPPI,IntAct,OmniPath
VPS35 SNX2 11102511 24234451 25348397 physical association molecular sieving,physical interaction ComPPI,IntAct
VPS35 TTC4 25348397 N/A physical interaction ComPPI
VPS35 VPS36 25348397 N/A physical interaction ComPPI
VPS35 HDLBP 25348397 N/A physical interaction ComPPI
VPS35 TRMT61A 25348397 N/A physical interaction ComPPI
VPS35 UPF1 25348397 N/A physical interaction ComPPI
VPS35 VPS33B 25348397 N/A physical interaction ComPPI
VPS35 PPP1R14C 25348397 N/A physical interaction ComPPI
VPS35 UBE4B 25348397 N/A physical interaction ComPPI
VPS35 TRMT6 25348397 N/A physical interaction ComPPI
VPS35 THUMPD3 25348397 N/A physical interaction ComPPI
VPS35 USP48 25348397 N/A physical interaction ComPPI
VPS35 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
VPS35 MAGEL2 25348397 N/A physical interaction ComPPI
VPS35 ITGA4 25348397 N/A physical interaction ComPPI
VPS35 IGSF8 25348397 N/A physical interaction ComPPI
VPS35 VEGFA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VPS35 ANP32E 25348397 N/A physical interaction ComPPI
VPS35 CORO1C 25348397 N/A physical interaction ComPPI
VPS35 NIBAN2 25348397 N/A physical interaction ComPPI
VPS35 NUDC 25348397 N/A physical interaction ComPPI
VPS35 PSAP 25348397 N/A physical interaction ComPPI
VPS35 SHMT2 25348397 N/A physical interaction ComPPI
VPS35 SNX6 25348397 N/A physical interaction ComPPI
VPS35 CYHR1 25348397 N/A physical interaction ComPPI
VPS35 IVNS1ABP 25348397 N/A physical interaction ComPPI
VPS35 OXR1 25348397 N/A physical interaction ComPPI
VPS35 RPL24 25348397 N/A physical interaction ComPPI
VPS35 TOLLIP 25348397 N/A physical interaction ComPPI
VPS35 RIOK2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
VPS35 ENO1 25348397 N/A physical interaction ComPPI
VPS35 MOV10 25348397 N/A physical interaction ComPPI
VPS35 NXF1 25348397 N/A physical interaction ComPPI
VPS35 MRM1 25348397 N/A physical interaction ComPPI
VPS35 MCM7 25348397 N/A physical interaction ComPPI
VPS35 RAB7A 25348397 N/A physical interaction ComPPI
VPS35 SLC11A2 25348397 N/A physical interaction ComPPI
VPS35 UNK 25348397 N/A physical interaction ComPPI
VPS35 VPS13A 25348397 N/A physical interaction ComPPI
VPS35 PCID2 25348397 N/A physical interaction ComPPI
VPS35 NTRK1 25348397 N/A physical interaction ComPPI
VPS35 SENP3 25348397 N/A physical interaction ComPPI
VPS35 FOXA1 25348397 N/A physical interaction ComPPI
VPS35 BRCA1 25348397 N/A physical interaction ComPPI
VPS35 LAMP2 25348397 N/A physical interaction ComPPI
VPS35 VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VPS35 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VPS35 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VPS35 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
VPS35 ATG9A 24234451 24603492 25348397 colocalization,physical association anti tag coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
VPS35 IGF2R 15078903 24234451 25348397 physical association two hybrid ComPPI,IntAct
VPS35 FKBP15 20923837 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
VPS35 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
WDR5 VPS35 25348397 N/A physical interaction ComPPI
VPS25 VPS35 25348397 N/A physical interaction ComPPI
ATP6V1C1 VPS35 25348397 N/A physical interaction ComPPI
VPS35 VPS51 11598206 15263065 17696874 17892535 27898060 9700157 N/A N/A OmniPath
ZBP1 VPS35 21903422 27898060 N/A N/A OmniPath

Visualization










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