GENE：PIP4K2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PIP4K2A |
| FullNmae | phosphatidylinositol-5-phosphate 4-kinase type 2 alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8997 |
| EnsembleID | ENSG00000150867 |
| Uniprot | P48426 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PIP4K2A | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| PIP4K2A | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| PIP4K2A | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PIP4K2A | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PIP4K2A | GO:0001750,GO:0001917,GO:0005515,GO:0005524,GO:0005654,GO:0005764,GO:0005776,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0010506,GO:0010506,GO:0016308,GO:0016308,GO:0016308,GO:0016309,GO:0016309,GO:0016310,GO:0035855,GO:0042803,GO:0046627,GO:0046854,GO:0061909,GO:0090119,GO:1902635,GO:2000786 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PIP4K2A | hsa:5305 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| PIP4K2A | hsa:5305 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PIP4K2A | hsa:5305 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| PIP4K2A | hsa:5305 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PIP4K2A | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | PIP4K2A | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PIP4K2A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | PIP4K2A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PIP4K2A | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PIP4K2A | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PIP4K2A | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PIP4K2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000048BA36 | PIP4K2A | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00003380CC | PIP4K2A | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002152A8 | PIP4K2A | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000AA464 | PIP4K2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000600E6 | PIP4K2A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | PIP4K2A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BD1DE | PIP4K2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004526F6 | PIP4K2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEE35 | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDA4 | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004D84DB | PIP4K2A | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | PIP4K2A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | PIP4K2A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | PIP4K2A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | PIP4K2A | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIN1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| LZTS2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| SKP1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| RAC1 | PIP4K2A | 14525934 25348397 7629060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| AP3M1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| BTK | PIP4K2A | 14525934 14614850 15046600 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| TEC | PIP4K2A | 14525934 14614854 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| JUN | PIP4K2A | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| UBTF | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CSNK2A1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| AFF1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| RAD18 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| NOS1AP | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| RAB11FIP1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| GRK5 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KB1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| ZRANB2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CSNK2A2 | PIP4K2A | 23455922 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| EPB41L3 | PIP4K2A | 24234451 24366813 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GTF2F1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| NOLC1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CCNT1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| ELL | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| STK11 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2B | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| STRADB | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| SBF1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| AP3B1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| SPEN | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| EAF2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| EAF1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PIP5K1A | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| ACIN1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PPRC1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| BRD4 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CAB39 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| STRADA | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| AFF4 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PNN | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| MLLT1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| SRRM2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| RNPS1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PNISR | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PPIG | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| SRSF8 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CLASRP | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CSNK2B | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| IFI16 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| GPATCH8 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CWC22 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| ARL6IP4 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| ELL2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| MED4 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| SETD2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| BRD3 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| TCOF1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| CXXC1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| GPBP1L1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| MLLT3 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| LENG8 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| NKAP | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| C18ORF25 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | GSTK1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| PIP4K2A | DDX23 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | MTPN | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | PRPF8 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | DIP2C | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | AFF3 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | RTF1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | HDGFL2 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | PIP4K2C | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | MEX3B | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | ELL3 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | CHD9 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | AHCYL2 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | NAF1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | GPALPP1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | MEX3C | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | BRPF1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | SETD1B | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | AHCYL1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | KANK1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | CUSTOS | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | DNAJC13 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | PLCD3 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | NFKBIL1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | RFWD3 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | JMJD6 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | IWS1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | EDC4 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | SELENOH | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | ARHGAP22 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | CCDC102A | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | WDR26 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | PRICKLE3 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | NEMP1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | MTMR1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | CHD8 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | EPB41L5 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | CCDC9 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | ZNF428 | 25348397 | N/A | physical interaction | ComPPI |
| PIP4K2A | SUN2 | 25348397 | N/A | physical interaction | ComPPI |
| ST6GAL1 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| PRKD1 | PIP4K2A | 16563698 27898060 | inhibition | N/A | OmniPath |
| CASP3 | PIP4K2A | 11042212 27898060 | inhibition | N/A | OmniPath |
| CSNK2A1 | PIP4K2A | 10508590 27898060 | stimulant | N/A | OmniPath |
| ARHGAP1 | PIP4K2A | 27898060 8868471 | stimulant | N/A | OmniPath |