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GENE：PAK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAK1
FullNmae p21 (RAC1) activated kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8590
EnsembleID ENSG00000149269
Uniprot Q13153

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAK1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAK1 GO:0001726,GO:0001934,GO:0002223,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005518,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005737,GO:0005815,GO:0005829,GO:0005829,GO:0005884,GO:0005886,GO:0005886,GO:0005911,GO:0005925,GO:0006338,GO:0006468,GO:0006468,GO:0006887,GO:0006915,GO:0006974,GO:0008284,GO:0014704,GO:0016310,GO:0016477,GO:0030018,GO:0030027,GO:0030036,GO:0030036,GO:0030335,GO:0030424,GO:0030425,GO:0031116,GO:0031267,GO:0031965,GO:0032587,GO:0032956,GO:0032991,GO:0033138,GO:0033148,GO:0035556,GO:0038096,GO:0042060,GO:0043015,GO:0043408,GO:0043507,GO:0046777,GO:0048012,GO:0048013,GO:0048754,GO:0048812,GO:0050770,GO:0051179,GO:0051496,GO:0060244,GO:0090063,GO:0106310,GO:1903608

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAK1 hsa:5058 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04360 Axon guidance - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04392 Hippo signaling pathway - multiple species - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04510 Focal adhesion - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PAK1 hsa:5058 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PAK1 hsa:5058 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
PAK1 hsa:5058 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
PAK1 hsa:5058 path:hsa05132 Salmonella infection - Homo sapiens (human)
PAK1 hsa:5058 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PAK1 hsa:5058 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PAK1 hsa:5058 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NCK1 PAK1 11278553 16490784 23109003 23180781 24670066 26192618 9024622 interaction type,physical association,chemical activation reaction anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink
NCK2 PAK1 24670066 26192618 interaction type N/A ACSN
PAK1 LIMK1 10461188 10467124 10511705 10559936 10613909 10661401 11018042 11062502 11121431 11340065 11385609 11413130 11907067 11950587 12054568 12885870 14749719 14764585 15157156 15229651 15536084 15713627 16293614 16702231 17522712 22154077 26192618 8625410 9843499 interaction type N/A ACSN
RAC1 PAK1 10224076 11121431 11274345 11544274 11756498 11950930 12650940 12879077 15157156 15229651 18000759 19151919 21474670 23180781 23331499 24459205 26192618 27331412 9032259 9655398 interaction type,stimulation,physical association two hybrid,pull down ACSN,InnateDB,SignaLink
PAK1 BAD 10230394 10461188 10467124 10511705 10558990 10559936 10611223 10613909 10661401 10837486 11018042 11062502 11121431 11340065 11385609 11413130 11493700 11907067 11950587 12054568 12885870 12954615 14749719 14764585 15157156 15229651 15280015 15536084 15713627 16293614 16702231 17270021 17522712 22154077 23109003 26192618 8625410 8929531 9346240 9381178 9843499 interaction type,inhibition N/A ACSN,SignaLink
PAK1 MAP2K3 10661401 11062502 11385609 11907067 12885870 14764585 15536084 23331499 26192618 7592586 interaction type,stimulation N/A ACSN,SignaLink
RAF1 PAK1 11733498 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
PAK1 PRKG1 16490784 23180781 phosphorylation reaction protein kinase assay InnateDB
VASP PAK1 16490784 23180781 physical association anti tag coimmunoprecipitation InnateDB
PAK1 PAK1 10980699 10995762 11804587 12228228 15710605 23180781 26467481 7618083 phosphorylation reaction,bind,up-regulates,up-regulates activity,down-regulates activity protein kinase assay InnateDB,Signor
PDPK1 PAK1 10995762 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
MAP2K1 PAK1 23180781 9351825 phosphorylation reaction protein kinase assay InnateDB
AKT1 PAK1 14585966 23180781 phosphorylation reaction protein kinase assay InnateDB
NCF1 PAK1 12855698 16099876 23180781 7618083 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
PAK1 CYBA 16099876 23180781 physical association pull down InnateDB
PAK1 CYBB 16099876 23180781 physical association pull down InnateDB
PTK2 PAK1 11278553 23180781 physical association anti tag coimmunoprecipitation InnateDB
ARHGEF7 PAK1 17392278 23180781 phosphorylation reaction anti tag coimmunoprecipitation,protein kinase assay InnateDB
MYLK PAK1 10092231 23180781 phosphorylation reaction protein kinase assay InnateDB
PAK1 ESR1 12374744 16452229 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay InnateDB
PAK1 H3-3A 12151336 23180781 phosphorylation reaction,physical association pull down,protein kinase assay InnateDB
PAK1 STMN1 14645234 23180781 phosphorylation reaction protein kinase assay InnateDB
NF2 PAK1 11719502 23180781 phosphorylation reaction protein kinase assay InnateDB
BAD PAK1 10611223 23180781 phosphorylation reaction protein kinase assay InnateDB
PAK1 SPEN 15824732 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,two hybrid,pull down,protein kinase assay InnateDB
PAK1 CASP1 15561713 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay InnateDB
PAK1 ELF3 17491012 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay InnateDB
PAK1 SNAI1 15833848 23180781 phosphorylation reaction protein kinase assay InnateDB
ILK PAK1 17420447 23180781 phosphorylation reaction protein kinase assay InnateDB
MAP3K1 PAK1 12228228 23180781 phosphorylation reaction protein kinase assay InnateDB
PAK1 PGM1 15378030 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,two hybrid,pull down,protein kinase assay InnateDB
CTTN PAK1 12453877 23180781 physical association pull down,protein kinase assay InnateDB
RAC2 PAK1 10224076 23180781 23331499 9705280 stimulation,physical association pull down InnateDB,SignaLink
PAK1 CDC42 10224076 23180781 physical association pull down InnateDB
PAK1 RAF1 11948406 23331499 stimulation N/A SignaLink,SignaLink
CRIPAK PAK1 16278681 23331499 stimulation N/A SignaLink,SignaLink
CDC42 PAK1 12650940 23109003 23331499 8107774 8973630 stimulation,chemical activation reaction N/A SignaLink,SignaLink
PAK1 MAP2K1 23331499 9351825 stimulation N/A SignaLink
PAK1IP1 PAK1 11371639 23331499 stimulation N/A SignaLink
MAPK3 PAK1 14993270 23331499 inhibition N/A SignaLink
PAK1 NCK1 10026169 11157752 23331499 8824201 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BAIAP2 PAK1 20005715 interaction type N/A PSP,SignaLink
CRIPAK PAK1 20005715 interaction type N/A PSP,SignaLink
FRS2 PAK1 20005715 interaction type N/A PSP,SignaLink
GRB2 PAK1 20005715 interaction type N/A PSP,SignaLink
HGS PAK1 20005715 interaction type N/A PSP
NCK1 PAK1 20005715 interaction type N/A PSP
NCK2 PAK1 20005715 interaction type N/A PSP,SignaLink
NF2 PAK1 20005715 interaction type N/A PSP,SignaLink
PAK1IP1 PAK1 20005715 interaction type N/A PSP
PXN PAK1 20005715 interaction type N/A PSP,SignaLink
SHC1 PAK1 20005715 interaction type N/A PSP,SignaLink
YWHAG PAK1 20005715 interaction type N/A PSP
HGS PAK1 11397816 20005715 21071413 N/A N/A SignaLink
NCK1 PAK1 20005715 20005715 21071413 8824201 N/A N/A SignaLink
PAK1IP1 PAK1 20005715 20005715 N/A N/A SignaLink
YWHAG PAK1 20005715 20005715 20936779 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PAK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PAK1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PAK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PAK1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PAK1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PAK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PAK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HLX PAK1 22897850 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000007F792 PAK1 18716028 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000007F792 PAK1 18716028 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00003380CC PAK1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 PAK1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BE495 PAK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PAK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 PAK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 PAK1 23333386 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002C02E4 PAK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 PAK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 PAK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 PAK1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D PAK1 25416803 26924291 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000122ED0 PAK1 25416803 26884926 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 PAK1 22135298 phosphorylation N/A PhosphoSite
STK11 PAK1 22135298 phosphorylation N/A PhosphoSite
BMX PAK1 22135298 phosphorylation N/A PhosphoSite
PDPK1 PAK1 22135298 phosphorylation N/A PhosphoSite
JAK2 PAK1 22135298 phosphorylation N/A PhosphoSite
CDK19 PAK1 22135298 phosphorylation N/A PhosphoSite
PAK1 PGM1 22135298 phosphorylation N/A PhosphoSite
PAK1 FXR1 22135298 phosphorylation N/A PhosphoSite
PAK1 PAK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PAK1 ARPC1B 22135298 phosphorylation N/A PhosphoSite
PAK1 GNAZ 22135298 phosphorylation N/A PhosphoSite
PAK1 RAF1 22135298 phosphorylation N/A PhosphoSite
PAK1 ILK 22135298 phosphorylation N/A PhosphoSite
PAK1 BAD 22135298 phosphorylation N/A PhosphoSite
PAK1 ARHGEF2 22135298 phosphorylation N/A PhosphoSite
PAK1 MAP3K1 22135298 phosphorylation N/A PhosphoSite
PAK1 TBCB 22135298 phosphorylation N/A PhosphoSite
PAK1 KIF2C 22135298 phosphorylation N/A PhosphoSite
PAK1 PGAM1 22135298 phosphorylation N/A PhosphoSite
PAK1 ELF3 22135298 phosphorylation N/A PhosphoSite
PAK1 CRK 22135298 phosphorylation N/A PhosphoSite
PAK1 CTNNB1 22135298 phosphorylation N/A PhosphoSite
PAK1 MORC2 22135298 phosphorylation N/A PhosphoSite
PAK1 PXN 22135298 phosphorylation N/A PhosphoSite
PAK1 GIT1 22135298 phosphorylation N/A PhosphoSite
PAK1 PLK1 22135298 phosphorylation N/A PhosphoSite
PAK1 H3C1 22135298 phosphorylation N/A PhosphoSite
PAK1 ITGB3BP 22135298 phosphorylation N/A PhosphoSite
PAK1 MYL9 22135298 phosphorylation N/A PhosphoSite
PAK1 FLNA 22135298 phosphorylation N/A PhosphoSite
PAK1 SNAI2 22135298 phosphorylation N/A PhosphoSite
PAK1 SNAI1 22135298 phosphorylation N/A PhosphoSite
PAK1 ARHGDIA 22135298 phosphorylation N/A PhosphoSite
PAK1 PCBP1 22135298 phosphorylation N/A PhosphoSite
PAK1 CTTN 22135298 phosphorylation N/A PhosphoSite
PAK1 BRAF 22135298 phosphorylation N/A PhosphoSite
PAK1 DYNLL1 22135298 phosphorylation N/A PhosphoSite
PAK1 SPEN 22135298 phosphorylation N/A PhosphoSite
PAK1 AURKA 22135298 phosphorylation N/A PhosphoSite
PAK1 STMN1 22135298 phosphorylation N/A PhosphoSite
PAK1 NF2 22135298 phosphorylation N/A PhosphoSite
PAK1 PA2G4 22135298 phosphorylation N/A PhosphoSite
PAK1 RUNX3 22135298 phosphorylation N/A PhosphoSite
PAK1 LIMK1 22135298 phosphorylation N/A PhosphoSite
PAK1 PREX2 22135298 phosphorylation N/A PhosphoSite
PAK1 MAP2K1 22135298 phosphorylation N/A PhosphoSite
PAK1 CTBP1 22135298 phosphorylation N/A PhosphoSite
PAK1 ESR1 22135298 phosphorylation N/A PhosphoSite
PAK1 MYLK 22135298 phosphorylation N/A PhosphoSite
PAK1 VIM 22135298 phosphorylation N/A PhosphoSite
PAK1 RAC1 25361965 interaction type N/A PTMCode2
RAC1 PAK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 PAK1 23455922 24234451 25348397 25416956 association,physical association physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNW1 PAK1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLL1 PAK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
CDC42 PAK1 12606577 12879077 19596003 20936779 21029865 21167153 23175184 23455922 24234451 25348397 7744004 8107774 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,two hybrid pooling approach,imaging technique,in vitro,tandem affinity purification ComPPI,IntAct
SH3KBP1 PAK1 16407834 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLL2 PAK1 15845372 20889982 21988832 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
SORBS3 PAK1 25348397 N/A physical interaction ComPPI
PAK2 PAK1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
OXSR1 PAK1 25348397 N/A two hybrid,in vitro ComPPI
PCBP1 PAK1 17389360 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,phosphorylation reaction,physical interaction,protein kinase assay ComPPI,IntAct
ZNF418 PAK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
YWHAG PAK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo ComPPI,IntAct
SMAD4 PAK1 25348397 N/A in vivo ComPPI
RAC1 PAK1 11030651 11950930 12879077 15688026 16492808 17245428 19270716 19596003 19732720 20810653 20936779 21029865 21167153 21454543 22117219 22581261 24172987 24234451 24625804 24792722 25348397 25843002 26175416 association,physical association anti tag coimmunoprecipitation,two hybrid,fluorescent resonance energy transfer,pull down,physical interaction,two hybrid pooling approach,in vitro,in vivo ComPPI,IntAct
CDK5R1 PAK1 25348397 N/A in vivo ComPPI
EIF3E PAK1 25348397 N/A two hybrid,physical interaction ComPPI
BAD PAK1 25348397 N/A physical interaction,in vitro ComPPI
H4C1 PAK1 25348397 N/A physical interaction,in vitro ComPPI
ERBB2 PAK1 25348397 N/A physical interaction,in vivo ComPPI
PAK1 MAP2K1 25348397 N/A in vitro,in vivo ComPPI
PAK1 ARHGEF6 21900206 23455922 24234451 25348397 association,physical association two hybrid,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,IntAct
PAK1 NCK1 15784622 24234451 25348397 physical association pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
PAK1 MYLK 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PAK1 LIMK1 10559936 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,IntAct
PAK1 PXN 25348397 N/A in vitro ComPPI
PAK1 HGS 25348397 N/A physical interaction,in vivo ComPPI
PAK1 PDPK1 25348397 N/A in vitro ComPPI
PAK1 ARHGEF7 16101281 16407834 16492808 16628223 20936779 23455922 24234451 25348397 29997244 association,physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,classical fluorescence spectroscopy,nuclear magnetic resonance,pull down,physical interaction,two hybrid pooling approach,in vitro,in vivo,tandem affinity purification,luminescence based mammalian interactome mapping ComPPI,IntAct
PAK1 FOXL2 25348397 N/A in vitro,in vivo ComPPI
PAK1 ABI3 25348397 N/A physical interaction,in vitro ComPPI
PAK1 NF2 21481793 24234451 25348397 physical association anti tag coimmunoprecipitation,in vitro,in vivo ComPPI,IntAct
PAK1 PAK1IP1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PAK1 CDK11B 12624090 16413544 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
PAK1 RHOJ 25348397 N/A two hybrid,pull down,physical interaction,in vitro ComPPI
PAK1 PPM1F 25348397 N/A in vivo ComPPI
PAK1 ARPC1B 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PAK1 ARHGEF2 25348397 N/A physical interaction,in vitro ComPPI
PAK1 CSNK2A1 25348397 N/A in vivo ComPPI
PAK1 MAPK1 25348397 N/A in vitro,in vivo ComPPI
PAK1 CDK11A 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PAK1 ACVR1 25348397 N/A in vivo ComPPI
PAK1 BMPR1B 25348397 N/A in vivo ComPPI
PAK1 SMAD1 25348397 N/A in vivo ComPPI
PAK1 SMAD2 25348397 N/A in vivo ComPPI
PAK1 SMURF1 25348397 N/A in vivo ComPPI
PAK1 RHOU 15556869 18086875 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction,in vitro ComPPI,IntAct
PAK1 EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction,in vitro,in vivo ComPPI,IntAct
PAK1 GRB2 25348397 N/A in vitro,in vivo ComPPI
PAK1 SYN1 25348397 N/A in vitro ComPPI
PAK1 DSCAM 25348397 N/A in vitro,in vivo ComPPI
PAK1 COL1A1 25348397 N/A in vitro ComPPI
PAK1 PRKCD 25348397 N/A in vivo ComPPI
PAK1 ACTA1 25348397 N/A in vivo ComPPI
PAK1 MBP 25348397 N/A in vitro ComPPI
PAK1 AKT1 23397142 24234451 25348397 physical association physical interaction,in vivo,proximity ligation assay ComPPI,IntAct
PAK1 NCF1 25348397 N/A in vivo ComPPI
PAK1 FRS2 25348397 N/A in vitro ComPPI
PAK1 GIT2 16628223 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
PAK1 TGFBR2 25348397 N/A physical interaction,in vivo ComPPI
PAK1 CDK5 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PAK1 FLNA 25348397 N/A two hybrid,two hybrid,physical interaction,in vitro,in vivo ComPPI
PAK1 SORBS2 15784622 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,in vitro,in vivo ComPPI,IntAct
PAK1 SHC1 25348397 N/A in vitro ComPPI
PAK1 ESR1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PAK1 FOXO1 25348397 N/A in vivo ComPPI
PAK1 CASP1 25348397 N/A in vitro,in vivo ComPPI
PAK1 RAF1 17097642 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay,in vitro,in vivo ComPPI,IntAct
PAK1 PKLR 25348397 N/A physical interaction ComPPI
PAK1 PLCG1 25348397 N/A physical interaction ComPPI
PAK1 BAIAP2 25348397 N/A physical interaction ComPPI
PAK1 HSP90AA1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 HSP90AA2P 25348397 N/A physical interaction ComPPI
PAK1 YWHAZ 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 DYRK1B 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 ZBTB18 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 ZC3H7A 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 ZNF823 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 ZNF83 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 MYNN 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 CPLANE1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAK1 TGM2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAK1 ELF3 25348397 N/A physical interaction ComPPI
PAK1 GNB1 25348397 N/A physical interaction ComPPI
PAK1 MAP3K1 25348397 N/A physical interaction ComPPI
PAK1 MYO6 25348397 N/A physical interaction ComPPI
PAK1 TGFBR1 25348397 N/A physical interaction ComPPI
PAK1 APP 25348397 N/A physical interaction ComPPI
PAK1 CRIPAK 16278681 24234451 25348397 phosphorylation reaction,colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,protein kinase assay,confocal microscopy ComPPI,IntAct
PAK1 CHORDC1 25348397 N/A physical interaction ComPPI
PAK1 LYN 25348397 N/A physical interaction ComPPI
PAK1 FBXO28 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PAK1 GIT1 16628223 23455922 24234451 25348397 25852190 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PAK1 BRSK1 22669945 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PAK1 PYCARD 24234451 25348397 25402006 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK1 H2AX 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK1 SLC25A41 25348397 N/A physical interaction ComPPI
PAK1 TAS2R41 25348397 N/A physical interaction ComPPI
PAK1 ILKAP 25348397 N/A physical interaction ComPPI
PAK1 PPAT 25348397 N/A physical interaction ComPPI
PAK1 RELA 25348397 N/A physical interaction ComPPI
PAK1 ICAM1 25348397 N/A physical interaction ComPPI
PAK1 LPXN 25348397 N/A physical interaction ComPPI
PAK1 FSD1 25348397 N/A physical interaction ComPPI
PAK1 OR2K2 25348397 N/A physical interaction ComPPI
PAK1 SETX 25348397 N/A physical interaction ComPPI
PAK1 FGB 25348397 N/A physical interaction ComPPI
PAK1 PPM1A 25348397 N/A physical interaction ComPPI
PAK1 PPP2CA 25348397 N/A physical interaction ComPPI
PAK1 PPP1CA 25348397 N/A physical interaction ComPPI
PAK1 MAPK14 25348397 N/A physical interaction ComPPI
PAK1 TBCB 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 PGM1 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 RPL7A 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 RPL27A 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 SRSF5 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 SRSF2 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 HNRNPAB 25348397 N/A two hybrid,physical interaction ComPPI
PAK1 ATG5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAK1 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAK1 CTTN 18344974 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PAK1 PLK1 20869364 24234451 25348397 physical association pull down ComPPI,IntAct
PAK1 SRGAP2 20810653 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK1 RAC2 25348397 N/A pull down ComPPI
PAK1 RAC3 25348397 N/A pull down ComPPI
PAK1 LRRK2 21454543 24234451 25348397 physical association pull down ComPPI,IntAct
PAK1 CIB1 16061695 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAK1 CAV1 24234451 24625804 25348397 association pull down ComPPI,IntAct
PAK1 TNFRSF10B 24234451 25348397 25843002 association pull down ComPPI,IntAct
PAK1 TNFSF10 24234451 25348397 25843002 association pull down ComPPI,IntAct
PAK1 PIK3CB 24234451 25348397 25843002 association pull down ComPPI,IntAct
PAK1 RPS6KB1 23175184 24234451 25348397 association pull down ComPPI,IntAct
RHOQ PAK1 25348397 N/A pull down ComPPI
CSNK2A2 PAK1 25348397 N/A in vivo ComPPI
SOX2 PAK1 25348397 N/A physical interaction ComPPI
BMX PAK1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
H3C1 PAK1 25348397 N/A physical interaction ComPPI
PAK1 PAK1 20936779 24234451 physical association two hybrid pooling approach IntAct
CDK5 PAK1 11604394 12176334 19413330 19664994 19664995 20058876 27898060 inhibition N/A OmniPath
PRKG1 PAK1 16490784 27898060 N/A N/A OmniPath
PAK1 CTNNB1 21822311 27898060 stimulant N/A OmniPath
PAK1 SYN1 12237306 14557263 27898060 inhibition N/A OmniPath
PAK1 CASP1 15561713 27898060 stimulant N/A OmniPath
PAK1 STMN1 10913145 14645234 19162178 27898060 7925472 8245003 8325880 inhibition N/A OmniPath
PAK1 CTTN 10537323 12453877 18344974 20444238 21079800 21856159 24753582 24867096 26490115 27898060 stimulant N/A OmniPath
VASP PAK1 16490784 27898060 N/A N/A OmniPath
PAK1 FLNA 12198493 27898060 stimulant N/A OmniPath
PAK1 GNAZ 10531372 27898060 8429024 9166747 stimulant N/A OmniPath
PAK1 PLK1 18427546 20869364 27898060 stimulant N/A OmniPath
RILPL2 PAK1 19812310 27898060 stimulant N/A OmniPath
RAC3 PAK1 17625931 27898060 stimulant N/A OmniPath
PAK1 MAP2K1 11684694 12609978 12876277 14993270 16129686 27898060 7873542 9351825 9416003 stimulant N/A OmniPath
STK11 PAK1 20400510 27898060 inhibition N/A OmniPath
PAK1 MYL9 10092231 10704379 11673466 12081505 12716456 15056655 15333633 15695393 17895359 18079119 18854160 21336303 25068972 26152729 26169356 27898060 3839510 N/A N/A OmniPath
RAC2 PAK1 10224076 27898060 9705280 stimulant N/A OmniPath
PAK1 RAC2 10224076 27898060 9705280 N/A N/A OmniPath
PAK1 MAP3K1 12228228 27898060 stimulant N/A OmniPath
PAK1 BRAF 10869359 11510412 15710605 27898060 N/A N/A OmniPath
CDK2 PAK1 12176333 27898060 inhibition N/A OmniPath
PAK1 FOXO1 10358014 12560069 27898060 N/A N/A OmniPath
PAK1 JUND 16007120 27898060 N/A N/A OmniPath
ESR1 PAK1 12374744 16452229 27898060 N/A N/A OmniPath
PAK1 ESR1 12138194 12374744 16452229 16741565 20043841 27898060 stimulant N/A OmniPath
CIB1 PAK1 16061695 27898060 stimulant N/A OmniPath
PAK1 BAD 10195903 10230394 10558990 10611223 10837486 10949026 11493700 12531792 12954615 14678993 15037618 15226424 15280015 15784622 15849194 15972258 16413544 17270021 18669648 18707149 19667065 20166139 21317286 22096607 27898060 8929531 9346240 9381178 inhibition N/A OmniPath
PDPK1 PAK1 10551809 10995762 11604394 27898060 stimulant N/A OmniPath
PAK1 MAPK6 18669648 19369195 21177870 27898060 N/A N/A OmniPath
AKT1 PAK1 12138087 14585966 14749719 23397142 24886428 27898060 stimulant N/A OmniPath
PAK1 WEE1 15037762 27898060 inhibition N/A OmniPath
PPM1A PAK1 18586681 27898060 N/A N/A OmniPath
PAK1 H3C1 12151336 27898060 stimulant N/A OmniPath
NCK1 PAK1 10026169 10330411 10372803 10805734 11096073 11157752 11278241 11278553 11557983 15784622 16490784 27898060 8798379 8824201 9024622 9755165 9851874 stimulant N/A OmniPath
PAK1 NCK1 10026169 10330411 10372803 10805734 11157752 11278241 11278553 11557983 15784622 16490784 27898060 8798379 8824201 9851874 stimulant N/A OmniPath
PTK2 PAK1 11278553 27898060 stimulant N/A OmniPath
PDK1 PAK1 10995762 27898060 stimulant N/A OmniPath
PPM1F PAK1 11864573 20016286 27898060 inhibition N/A OmniPath
PAK1 MAP2K3 27898060 7592586 stimulant N/A OmniPath
PAK1 AURKA 24867643 27898060 stimulant N/A OmniPath
CHP1 PAK1 10562284 27898060 9778532 stimulant N/A OmniPath
RAC1 PAK1 10023776 10224076 10706722 10802735 11030651 11130076 11134022 11728826 11950930 12650940 12879077 14579272 14580336 15075243 15673687 15688026 16002993 16368433 16492808 16551621 16678097 17245428 19270716 19327867 19596003 19732720 19961560 20711231 20936779 21070974 21167153 21474670 22117219 22581261 24792722 27898060 7493928 7744004 8107774 8805275 8910277 9032259 9535855 9601050 9744077 stimulant N/A OmniPath
PAK1 RAC1 10023776 10224076 10706722 10802735 11030651 11130076 11134022 11728826 11950930 12650940 12879077 14579272 14580336 15075243 15673687 15688026 16002993 16368433 16492808 16551621 16678097 17245428 19270716 19327867 19596003 19732720 19961560 20936779 21167153 21474670 22117219 22581261 24792722 27898060 7493928 7744004 8107774 8805275 8910277 9032259 9535855 9601050 9744077 inhibition N/A OmniPath
GRB2 PAK1 12522133 27898060 stimulant N/A OmniPath
RHOU PAK1 11459829 15556869 18086875 27898060 stimulant N/A OmniPath
MAPK3 PAK1 14993270 27898060 inhibition N/A OmniPath
PAK1 ADAM17 12621058 27898060 N/A N/A OmniPath
PAK1 ABL1 11121037 12644574 15696159 16464493 27898060 stimulant N/A OmniPath
PAK1 PXN 10330411 11096073 16717130 17440071 23317503 27898060 stimulant N/A OmniPath
PAK1 CTBP1 12872159 18184656 23291169 27898060 inhibition,stimulant N/A OmniPath
PAK1IP1 PAK1 11371639 27898060 inhibition N/A OmniPath
FMR1 PAK1 17592139 27898060 stimulant N/A OmniPath
PAK1 CRK 12198159 22848689 27898060 9480991 9642287 N/A N/A OmniPath
PAK1 RAF1 10205168 10801448 11134016 11733498 11948406 12551923 15849194 17097642 18465753 18775988 21917714 27898060 9234708 9823899 stimulant N/A OmniPath
ERBB2 PAK1 27898060 9774445 stimulant N/A OmniPath
PAK1 ARPC1B 14749719 26160174 27898060 stimulant N/A OmniPath
PAK1 DYNLL1 15193260 18084006 18650427 19289209 19863079 20889982 21062069 21988832 23038268 27898060 inhibition N/A OmniPath
MAPK1 PAK1 15542607 27898060 stimulant N/A OmniPath
PAK1 VIM 15766329 16140754 16629900 16990256 16997882 17024653 18653473 18983824 19270731 21465480 24073199 24282534 26369929 26499837 27898060 7983050 stimulant N/A OmniPath
CSNK2A1 PAK1 10938077 23885116 27898060 N/A N/A OmniPath
PPP2CA PAK1 10322434 18586681 27898060 inhibition N/A OmniPath
PAK1 KIF2C 23055517 27898060 inhibition N/A OmniPath
CDC42 PAK1 10224076 10360579 10684602 10802735 12606577 12650940 12879077 16678097 18057010 19596003 20936779 21070974 21167153 23455922 24276241 27898060 7493928 7592896 7744004 810774 8107774 9535855 9601050 9705280 stimulant N/A OmniPath
PAK1 CDC42 10224076 10360579 10684602 10802735 12606577 12650940 12879077 16678097 18057010 19596003 20936779 21167153 23455922 24276241 27898060 7493928 7592896 7744004 8107774 9535855 9601050 9705280 stimulant N/A OmniPath
PAK1 ERBB3 11546794 27898060 9516479 9694850 N/A N/A OmniPath
PAK1 LIMK1 10559936 10652353 11340065 11413130 15660133 27898060 stimulant N/A OmniPath
PAK1 ARAF 15710605 27898060 stimulant N/A OmniPath
JAK2 PAK1 17726028 21566085 21719533 23340249 25125660 25466889 27898060 N/A N/A OmniPath
PPM1E PAK1 11864573 27898060 inhibition N/A OmniPath
RHOQ PAK1 27898060 9799731 stimulant N/A OmniPath
PAK1 H3-3A 12151336 27898060 N/A N/A OmniPath
PAK1 SNAI1 15647282 15833848 27898060 stimulant N/A OmniPath
NCF1 PAK1 12855698 16099876 27898060 7618083 N/A N/A OmniPath
PAK1 NCF1 12855698 16099876 27898060 7618083 stimulant N/A OmniPath
PAK1 ARHGEF7 10330411 11096073 11157752 16101281 16407834 16492808 16628223 17392278 20936779 23455922 27898060 9659915 9726964 stimulant N/A OmniPath
ARHGEF7 PAK1 10330411 11157752 16101281 16407834 16492808 16628223 17392278 20936779 23455922 27898060 N/A N/A OmniPath
PAK1 HACE1 27898060 29362425 inhibition N/A OmniPath
NF2 PAK1 11719502 14580336 21481793 27898060 inhibition N/A OmniPath
PAK1 NF2 11719502 14580336 18071304 18669648 19651622 19691289 20068231 21481793 27898060 inhibition,stimulant N/A OmniPath
PAK1 PCBP1 17389360 27898060 N/A N/A OmniPath
PAK1 ARHGDIA 15225553 27898060 inhibition,stimulant N/A OmniPath
PAK1 SPEN 15824732 27898060 N/A N/A OmniPath
PAK1 ARHGEF2 14970201 15827085 17488622 18669648 19667072 19690332 27898060 inhibition N/A OmniPath
PAK1 ILK 17420447 22521536 25738875 27898060 stimulant N/A OmniPath
PAK1 MYLK 10092231 27898060 inhibition N/A OmniPath
MAP4K1 PAK1 11134074 27898060 N/A N/A OmniPath
ELF3 PAK1 17491012 27898060 N/A N/A OmniPath
PAK1 ELF3 17491012 27898060 stimulant N/A OmniPath
PAK1 PGM1 15378030 27898060 stimulant N/A OmniPath
PAK1 GIT1 16628223 16797488 23455922 25852190 27898060 N/A N/A OmniPath
PAK1 MBP 11435472 12374744 14579272 27898060 N/A N/A OmniPath
PAK1 PA2G4 18283314 27898060 stimulant N/A OmniPath
PAK1 MAPK4 18669648 21177870 27898060 N/A N/A OmniPath
CDK19 PAK1 19520772 27898060 N/A N/A OmniPath
CRIPAK PAK1 16278681 27898060 inhibition,stimulant N/A OmniPath
PAK1 ITGB3BP 18521086 25409762 27898060 stimulant N/A OmniPath
PAK1 CTPS1 17189248 17463002 17681942 27898060 N/A N/A OmniPath
OXSR1 PAK1 14707132 27898060 inhibition N/A OmniPath
PPP2CB PAK1 10322434 18586681 27898060 N/A N/A OmniPath
PAK1 TBCB 15831477 18048340 27898060 stimulant N/A OmniPath
PAK1 PGAM1 12189148 27898060 inhibition N/A OmniPath
PAK1 RGS10 11443111 27898060 N/A N/A OmniPath
PAK1 FOXL2 12560069 27898060 N/A N/A OmniPath
PAK1 ASIC1 12578970 27898060 N/A N/A OmniPath
PAK1 MORC2 23260667 25888627 27898060 N/A N/A OmniPath
PAK1 FXR1 20417602 27898060 N/A N/A OmniPath
PAK1 CAVIN1 15242332 27898060 N/A N/A OmniPath

Visualization










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