GENE:RRAGC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RRAGC |
| FullNmae | Ras related GTP binding C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:19902 |
| EnsembleID | ENSG00000116954 |
| Uniprot | Q9HB90 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RRAGC | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RRAGC | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RRAGC | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RRAGC | GO:0000287,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005525,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005764,GO:0005765,GO:0005829,GO:0006351,GO:0006915,GO:0007264,GO:0008104,GO:0008380,GO:0009267,GO:0010507,GO:0019003,GO:0019003,GO:0031669,GO:0032006,GO:0034198,GO:0043200,GO:0043231,GO:0043495,GO:0046982,GO:0051020,GO:0060090,GO:0061462,GO:0071230,GO:0072657,GO:0140767,GO:1903432,GO:1904263,GO:1904263,GO:1990131,GO:1990877 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RRAGC | hsa:64121 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| RRAGC | hsa:64121 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| RRAGC | hsa:64121 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | RRAGC | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | RRAGC | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | RRAGC | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | RRAGC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | RRAGC | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | RRAGC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000ED600 | RRAGC | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | RRAGC | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | RRAGC | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000076995 | RRAGC | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000000B1C9 | RRAGC | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004719AB | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS00000B7E30 | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS000028DE3F | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip,clip | TarBase |
| URS00003003B4 | RRAGC | 21572407 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00004407DC | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B59DF | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008F0CF | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F4657 | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | RRAGC | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015188E | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CE0C6 | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | RRAGC | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EC3B | RRAGC | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000277201 | RRAGC | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000202460 | RRAGC | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LGALS3 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| TBC1D7 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| TRAF6 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR4 | RRAGC | 22980980 24234451 25348397 25561175 | association | affinity chromatography technology,anti tag coimmunoprecipitation | ComPPI,IntAct |
| LGALS9C | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR3 | RRAGC | 20381137 22980980 24234451 25348397 25561175 | association | affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SQSTM1 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| TSC2 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| TSC1 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| LGALS8 | RRAGC | 25348397 | N/A | physical interaction | ComPPI |
| RAB9A | RRAGC | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MPP3 | RRAGC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MTOR | RRAGC | 24234451 25348397 25446900 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| ATP6V1A | RRAGC | 24234451 25348397 25561175 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| LAMTOR2 | RRAGC | 20381137 22980980 24234451 25348397 25561175 25567906 | association | affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPTOR | RRAGC | 24234451 25348397 25446900 25561175 25567906 | association,physical association | anti tag coimmunoprecipitation,physical interaction,proximity ligation assay | ComPPI,IntAct |
| RRAGC | RRAGB | 11073942 14525934 20381137 22424946 24234451 25348397 25561175 25567906 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| RRAGC | RRAGA | 11073942 14525934 16189514 20381137 22424946 24234451 25348397 25561175 25567906 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| RRAGC | NOL8 | 14525934 14660641 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| RRAGC | ATXN1L | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | LAMTOR1 | 20381137 22424946 22980980 24234451 25348397 25561175 25567906 | colocalization,association | affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy | ComPPI,IntAct |
| RRAGC | WNT2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| RRAGC | RRAGD | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | MIOS | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | WDR24 | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | DEPDC5 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction,physical interaction | ComPPI |
| RRAGC | FPR2 | 25348397 | N/A | physical interaction | ComPPI |
| RRAGC | SLC38A9 | 24234451 25348397 25561175 25567906 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RRAGC | LAMTOR5 | 22980980 24234451 25348397 25561175 | association | affinity chromatography technology,anti tag coimmunoprecipitation | ComPPI,IntAct |
| ATP6V1B2 | RRAGC | 24234451 25348397 25561175 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| RRAGC | RRAGC | 11073942 14525934 14660641 | N/A | experimental interaction detection | HPRD |
| RPTOR | RRAGC | 18497260 21816923 21981924 24337580 25446900 27898060 | N/A | N/A | OmniPath |
| RRAGC | RPTOR | 18497260 20006481 21816923 21981924 24337580 25446900 27898060 | inhibition,stimulant | N/A | OmniPath |
| RRAGC | MTOR | 18497260 21981924 24337580 25446900 27898060 | inhibition | N/A | OmniPath |
