GENE:ATP6V0B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATP6V0B |
| FullNmae | ATPase H+ transporting V0 subunit b |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:861 |
| EnsembleID | ENSG00000117410 |
| Uniprot | Q99437 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATP6V0B | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATP6V0B | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| ATP6V0B | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| ATP6V0B | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATP6V0B | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATP6V0B | GO:0000139,GO:0000220,GO:0005515,GO:0005765,GO:0005765,GO:0005886,GO:0007035,GO:0007042,GO:0010008,GO:0010008,GO:0016020,GO:0016241,GO:0030665,GO:0030670,GO:0033176,GO:0046961,GO:0048388,GO:0051452,GO:0061795,GO:1902495,GO:1902600 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATP6V0B | hsa:533 | path:hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| ATP6V0B | hsa:533 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ATP6V0B | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ATP6V0B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ATP6V0B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | ATP6V0B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ATP6V0B | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000015F70F | ATP6V0B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012930C | ATP6V0B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | ATP6V0B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003677B2 | ATP6V0B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003B59DF | ATP6V0B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD02D | ATP6V0B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GLP1R | ATP6V0B | 25348397 | N/A | physical interaction | ComPPI |
| YWHAG | ATP6V0B | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| APOD | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| YWHAE | ATP6V0B | 25348397 | N/A | physical interaction | ComPPI |
| SNTA1 | ATP6V0B | 25348397 | N/A | physical interaction | ComPPI |
| IRAK3 | ATP6V0B | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| GJA8 | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| FAS | ATP6V0B | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| STOM | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MIP | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MS4A3 | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MTNR1B | ATP6V0B | 24234451 25348397 26514267 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| KLRC1 | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NXF1 | ATP6V0B | 25348397 | N/A | physical interaction | ComPPI |
| MOV10 | ATP6V0B | 25348397 | N/A | physical interaction | ComPPI |
| VMA21 | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| GPR61 | ATP6V0B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | NRM | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | SLC2A5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | FAM210B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | SLC10A1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | ADGRG3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | TM4SF19 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | GPR42 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATP6V0B | SPACA1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ADRB2 | ATP6V0B | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
