GENE：ATP13A2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATP13A2 |
| FullNmae | ATPase cation transporting 13A2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30213 |
| EnsembleID | ENSG00000159363 |
| Uniprot | Q9NQ11 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATP13A2 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| ATP13A2 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| ATP13A2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATP13A2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATP13A2 | GO:0000421,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005765,GO:0005765,GO:0005770,GO:0005771,GO:0005771,GO:0005776,GO:0006874,GO:0006874,GO:0006879,GO:0006882,GO:0006914,GO:0007041,GO:0008270,GO:0010628,GO:0010821,GO:0010821,GO:0010821,GO:0015203,GO:0015417,GO:0015662,GO:0016020,GO:0016020,GO:0016241,GO:0016241,GO:0016243,GO:0016243,GO:0016887,GO:0019829,GO:0019829,GO:0030003,GO:0030133,GO:0030145,GO:0031902,GO:0031982,GO:0032585,GO:0033157,GO:0034220,GO:0034599,GO:0034599,GO:0043005,GO:0043025,GO:0043202,GO:0043523,GO:0046777,GO:0050714,GO:0052548,GO:0055085,GO:0055088,GO:0061462,GO:0061909,GO:0061909,GO:0070300,GO:0071287,GO:0071287,GO:0071294,GO:0080025,GO:0097734,GO:0098655,GO:1900180,GO:1902047,GO:1903135,GO:1903146,GO:1903543,GO:1903543,GO:1903710,GO:1904714,GO:1905037,GO:1905165,GO:1905165,GO:1905166,GO:1990938,GO:2000152 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ATP13A2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ATP13A2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | ATP13A2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ATP13A2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | ATP13A2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ATP13A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATP13A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ATP13A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ATP13A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSPA8 | ATP13A2 | 22645275 24234451 25348397 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| VAMP2 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| ACTB | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction | ComPPI,IntAct |
| PTH1R | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| PEX19 | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| RAB7A | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| PDIA6 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| HIPK1 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| SEC61B | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| F2R | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| RAB5A | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| HDAC6 | ATP13A2 | 22645275 24234451 25348397 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| MYCBP2 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| SLC4A8 | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| RAB9A | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| FKBP8 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| CXCR4 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| CD79B | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| COL1A1 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| GAK | ATP13A2 | 22645275 24234451 25348397 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| LRP6 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| DCAF7 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| MYH9 | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| ICAM2 | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| CCKBR | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| MEX3B | ATP13A2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| HLA-DPA1 | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| BNIP3L | ATP13A2 | 22645275 24234451 25348397 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| NRXN1 | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |
| ATP13A2 | LMAN2 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| ATP13A2 | AAK1 | 22645275 24234451 25348397 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| ATP13A2 | ACKR3 | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| ATP13A2 | OSTC | 22645275 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| ATP13A2 | ATL3 | 25348397 | N/A | physical interaction | ComPPI |
| ATP13A2 | RTEL1 | 25348397 | N/A | physical interaction | ComPPI |
| HAVCR2 | ATP13A2 | 25348397 | N/A | physical interaction | ComPPI |