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GENE：HERC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HERC1
FullNmae HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4867
EnsembleID ENSG00000103657
Uniprot Q15751

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HERC1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HERC1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HERC1 GO:0004842,GO:0005085,GO:0005737,GO:0005794,GO:0005829,GO:0006914,GO:0010507,GO:0016020,GO:0016567,GO:0021702,GO:0022038,GO:0031175,GO:0050885

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HERC1 hsa:8925 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HERC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HERC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HERC1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 HERC1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HERC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AD002 HERC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 HERC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D HERC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E HERC1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
BYSL HERC1 25348397 N/A physical interaction ComPPI
LAPTM5 HERC1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
JUN HERC1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
EP300 HERC1 14525934 16051665 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBC HERC1 25348397 N/A physical interaction ComPPI
HERC1 RNF11 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
HERC1 DFFA 25348397 N/A physical interaction ComPPI
HERC1 ARF1 25348397 N/A physical interaction ComPPI
HERC1 TSC2 25348397 N/A physical interaction ComPPI
HERC1 CLTC 25348397 27898060 9233772 N/A physical interaction ComPPI,OmniPath
HERC1 NOS2 25348397 N/A physical interaction ComPPI
HERC1 SOX9 25348397 N/A physical interaction ComPPI
HERC1 UBE2D3 25348397 N/A physical interaction ComPPI
HERC1 GRIPAP1 25348397 N/A physical interaction ComPPI
HERC1 KCMF1 25348397 N/A physical interaction ComPPI
HERC1 MYL12B 25348397 N/A physical interaction ComPPI
HERC1 BAK1 25348397 N/A physical interaction ComPPI
HERC1 BRCA1 25348397 N/A physical interaction ComPPI
HERC1 MLF1 25348397 N/A physical interaction ComPPI
HERC1 ECHS1 25348397 N/A physical interaction ComPPI
HERC1 RAPSN 25348397 N/A physical interaction ComPPI
HERC1 USP18 25348397 N/A physical interaction ComPPI
HERC1 TFDP3 25348397 N/A physical interaction ComPPI
HERC1 ARHGAP29 25348397 N/A physical interaction ComPPI
HERC1 UBE2S 25348397 N/A physical interaction ComPPI
HERC1 EGFR 25348397 N/A physical interaction ComPPI
HERC1 SSH3 25348397 N/A physical interaction ComPPI
HERC1 WDFY3 25348397 N/A physical interaction ComPPI
HERC1 TIGD6 25348397 N/A physical interaction ComPPI
HERC1 TRPC4AP 25348397 N/A physical interaction ComPPI
HERC1 CSNK1A1 25348397 N/A physical interaction ComPPI
HERC1 C1ORF87 25348397 N/A physical interaction ComPPI
HERC1 RABGEF1 25348397 N/A physical interaction ComPPI
HERC1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PKM HERC1 12650930 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
HMGN2 HERC1 24234451 30021884 physical association cross-linking study IntAct
CANX HERC1 24234451 30021884 physical association cross-linking study IntAct

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