GENE：MTCL1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MTCL1 |
| FullNmae | microtubule crosslinking factor 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29121 |
| EnsembleID | ENSG00000168502 |
| Uniprot | Q9Y4B5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MTCL1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTCL1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MTCL1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MTCL1 | GO:0000922,GO:0000922,GO:0001578,GO:0001578,GO:0003723,GO:0005615,GO:0005737,GO:0005856,GO:0008017,GO:0008017,GO:0010506,GO:0016324,GO:0016327,GO:0016327,GO:0016328,GO:0016328,GO:0030496,GO:0030496,GO:0042803,GO:0045197,GO:0045197,GO:0090314,GO:0097427,GO:0097427 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MTCL1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MTCL1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MTCL1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MTCL1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | MTCL1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | MTCL1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | MTCL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDC5L | MTCL1 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DYNLL1 | MTCL1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PPP2R1A | MTCL1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| AMOT | MTCL1 | 24234451 24255178 25348397 | colocalization | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| EGLN3 | MTCL1 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TUBA1B | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| CLK1 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| MARK4 | MTCL1 | 14676191 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MARK2 | MTCL1 | 19615732 20360068 23902687 24234451 25348397 26496610 27898060 | association,physical association | anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct,OmniPath |
| MARK3 | MTCL1 | 24234451 25348397 25852190 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TRIM25 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| RNF41 | MTCL1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SRPK2 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| NDEL1 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| TUBB3 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| NEDD1 | MTCL1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| STK40 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| NXF1 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| CAPZA2 | MTCL1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MOV10 | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R2C | MTCL1 | 25348397 | N/A | physical interaction | ComPPI |
| MTCL1 | PPP2R2B | 19156129 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MTCL1 | SAMHD1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |