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GENE：PLEKHG2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLEKHG2
FullNmae pleckstrin homology and RhoGEF domain containing G2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29515
EnsembleID ENSG00000090924
Uniprot Q9H7P9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLEKHG2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLEKHG2 GO:0005085,GO:0005515,GO:0005829,GO:0030833,GO:0030833,GO:0031267

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 PLEKHG2 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP PLEKHG2 21832049 23180781 physical association protein array InnateDB
ACTN3 PLEKHG2 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR PLEKHG2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PLEKHG2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1I2 PLEKHG2 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PLEKHG2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 PLEKHG2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EC1BE PLEKHG2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D PLEKHG2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 PLEKHG2 22012620 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00001C770D PLEKHG2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB PLEKHG2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C PLEKHG2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA PLEKHG2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD PLEKHG2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 PLEKHG2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF PLEKHG2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 PLEKHG2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B PLEKHG2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000358C16 PLEKHG2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 PLEKHG2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PLEKHG2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 PLEKHG2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F PLEKHG2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PLEKHG2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C PLEKHG2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000170CF4 PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021202F PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000259AE4 PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PLEKHG2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC PLEKHG2 22135298 phosphorylation N/A PhosphoSite
ABL1 PLEKHG2 22135298 phosphorylation N/A PhosphoSite
RAC1 PLEKHG2 25361965 interaction type N/A PTMCode2
PLEKHG2 RAC1 25361965 interaction type N/A PTMCode2
CDC42 PLEKHG2 25361965 interaction type N/A PTMCode2
PLEKHG2 CDC42 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 PLEKHG2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ACTN3 PLEKHG2 25348397 N/A physical interaction ComPPI
CDC42 PLEKHG2 11839748 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RAC1 PLEKHG2 11839748 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA PLEKHG2 11839748 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XRN1 PLEKHG2 25348397 N/A physical interaction ComPPI
GNG2 PLEKHG2 25348397 N/A physical interaction ComPPI
CCNA2 PLEKHG2 25348397 N/A physical interaction ComPPI
PLEKHG2 GNB1 25348397 N/A physical interaction ComPPI
PLEKHG2 APP 25348397 N/A physical interaction ComPPI
ABL1 PLEKHG2 24378532 27898060 N/A N/A OmniPath

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