GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
TMEM59
FullNmae
transmembrane protein 59
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:1239
EnsembleID
ENSG00000116209
Uniprot
Q9BXS4
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
TMEM59
autophagy
38538696
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
TMEM59
autophagy
36341760
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns.
regulator signature
Go Annotation:
GeneSymbol
Go id
TMEM59
GO:0000137,GO:0000138,GO:0000139,GO:0004175,GO:0005515,GO:0005764,GO:0005764,GO:0005765,GO:0005770,GO:0005770,GO:0005797,GO:0005886,GO:0006486,GO:0006914,GO:0010508,GO:0010508,GO:0031902,GO:0070062,GO:1903077
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
ETS1
TMEM59
20019798
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
GATA2
TMEM59
19941826
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
FOXP3
TMEM59
20554955
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
SMARCA4
TMEM59
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS0000065D58
TMEM59
18668040
25416803
mrna cleavage,inhibition
experimental interaction detection,experimental interaction detection,experimental interaction detection
TarBase
URS00001C770D
TMEM59
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS0000239117
TMEM59
23622248
25416803
mrna cleavage,inhibition
clash
TarBase
URS00001E0AEA
TMEM59
22473208
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000451A1
TMEM59
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS00005D986D
TMEM59
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000006B702
TMEM59
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS000006BE7D
TMEM59
23592263
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001F14FE
TMEM59
23446348
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001D4A78
TMEM59
23446348
25416803
mrna cleavage,inhibition
clip
TarBase
URS00005E6F45
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00002FF522
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000013D17D
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000006FDD4
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000DDD35
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000C5969
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00005ECFE5
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000184017
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001F0C23
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001A122A
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000005D4F5
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000047A67D
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00005CCD18
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000078918
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00000EE7F0
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00003B59DF
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001496AE
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000006372A
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS000041FA2C
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS0000355E82
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00001C0099
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
URS00003FBC84
TMEM59
23824327
25416803
mrna cleavage,inhibition
clip
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
ERRFI1
TMEM59
25348397
N/A
physical interaction
ComPPI
NTRK1
TMEM59
25348397
N/A
physical interaction
ComPPI
AP1M1
TMEM59
23376921
24234451
25348397
physical association
pull down
ComPPI,IntAct
PARP2
TMEM59
21812934
24234451
25348397
adp ribosylation reaction
protein array
ComPPI,IntAct
MAP1LC3A
TMEM59
23376921
24234451
25348397
colocalization
fluorescence microscopy
ComPPI,IntAct
CUL7
TMEM59
25348397
N/A
physical interaction
ComPPI
AP2M1
TMEM59
23376921
24234451
25348397
physical association
pull down
ComPPI,IntAct
ELAVL1
TMEM59
25348397
N/A
physical interaction
ComPPI
IL20RB
TMEM59
25348397
N/A
physical interaction
ComPPI
ATG16L1
TMEM59
23376921
24234451
25348397
physical association
pull down,physical interaction
ComPPI,IntAct
RYK
TMEM59
25348397
N/A
physical interaction
ComPPI
TMEM59
PDE3B
25348397
N/A
physical interaction
ComPPI
TMEM59
TMEM30A
25348397
N/A
physical interaction
ComPPI
Source
Target
Pmid
Interactiontype
Methods
Database
URS00009AD46B
TMEM59
27087310
direct interaction,inhibition
N/A
NPInter
Visualization