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GENE：RASA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RASA1
FullNmae RAS p21 protein activator 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9871
EnsembleID ENSG00000145715
Uniprot P20936

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RASA1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RASA1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RASA1 GO:0000281,GO:0001570,GO:0001726,GO:0001784,GO:0001953,GO:0003924,GO:0005096,GO:0005102,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007162,GO:0007165,GO:0008360,GO:0019870,GO:0030833,GO:0035556,GO:0043066,GO:0043524,GO:0048013,GO:0048514,GO:0051020,GO:0051252

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RASA1 hsa:5921 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RASA1 hsa:5921 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RASA1 hsa:5921 path:hsa04360 Axon guidance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ARHGAP35 RASA1 10769036 17517963 18829532 22411312 26192618 8360177 8537347 9819392 association N/A ACSN
RASA1 TSC1 17355907 23180781 physical association two hybrid InnateDB
SOCS1 RASA1 18556463 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP RASA1 21832049 23180781 physical association protein array InnateDB
IGF1R RASA1 18988627 23331499 7642582 stimulation N/A SignaLink,SignaLink
PDGFRB RASA1 10697503 11896619 23331499 stimulation N/A SignaLink
EPHB2 RASA1 10644995 23331499 9233798 stimulation N/A SignaLink
EPHB3 RASA1 23331499 9674711 stimulation N/A SignaLink
SOCS3 RASA1 11331873 23331499 stimulation N/A SignaLink
SRC RASA1 11389730 1717825 23331499 stimulation N/A SignaLink
LCK RASA1 11389730 1850098 23331499 stimulation N/A SignaLink
RASA1 CAV2 12091389 15504032 23331499 stimulation N/A SignaLink
RASA1 HRAS 23331499 9219684 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR RASA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RASA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 RASA1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 RASA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RASA1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RASA1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RASA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 RASA1 21868695 rna interference,inhibition experimental interaction detection,western blot miRSponge
URS0000001EB3 RASA1 23322774 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000237AF9 RASA1 20065103 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000237AF9 RASA1 20065103 25416803 25520857 26708214 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D RASA1 18372920 25416803 25663768 27876571 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000028BB8 RASA1 21868695 25416803 mrna cleavage,inhibition experimental interaction detection,western blot TarBase
URS0000001EB3 RASA1 23322774 25416803 26657862 26747707 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000160683 RASA1 19859982 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS000016FF9C RASA1 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS000006FDD4 RASA1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GMCL1 RASA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SOCS3 RASA1 11331873 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
YES1 RASA1 14525934 1544885 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDE6D RASA1 11786539 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
RACK1 RASA1 11350068 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ERBB2 RASA1 16273093 24234451 24412244 25348397 physical association protein array,physical interaction,two hybrid array ComPPI,IntAct
ARHGAP5 RASA1 14525934 25348397 8537347 N/A experimental interaction detection,in vivo ComPPI,HPRD
HRAS RASA1 14525934 24234451 25348397 2833817 7628625 8663024 9219684 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SYK RASA1 14525934 25348397 9218456 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTK2B RASA1 10713673 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EZH2 RASA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOCS1 RASA1 25348397 N/A physical interaction ComPPI
PAG1 RASA1 10790433 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ERBB4 RASA1 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
KIT RASA1 11071635 14525934 24234451 24728074 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,in vitro ComPPI,HPRD,IntAct
LYN RASA1 14525934 25348397 8395016 N/A experimental interaction detection,in vitro ComPPI,HPRD
PIK3R1 RASA1 1336372 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SRC RASA1 14525934 1717825 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DOK1 RASA1 14525934 25348397 9008161 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LCK RASA1 14525934 1850098 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KDR RASA1 10319320 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SHC1 RASA1 14525934 25348397 8155326 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NCK1 RASA1 10508618 14525934 21664272 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,far western blotting,mass spectrometry studies of complexes,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
EPHB2 RASA1 10644995 14525934 25348397 9233798 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP3 RASA1 10200531 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KHDRBS1 RASA1 11604231 14525934 24234451 25348397 7537265 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
GRB2 RASA1 12441060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RB1 RASA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CD5 RASA1 14525934 24234451 25348397 9603468 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
AR RASA1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
SMAD2 RASA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ZAP70 RASA1 14525934 25348397 7760813 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ARHGAP1 RASA1 14525934 25348397 9034330 N/A experimental interaction detection,in vitro ComPPI,HPRD
WWP1 RASA1 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
SDC2 RASA1 22471946 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
MAP4K4 RASA1 25348397 N/A physical interaction,in vivo ComPPI
PDGFRB RASA1 10697503 1314164 1375321 14525934 24234451 25348397 8382774 association biophysical,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FES RASA1 14525934 25348397 7691175 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SYN1 RASA1 10899172 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SLC9A2 RASA1 10187839 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GAB1 RASA1 15574420 24234451 24728074 25348397 association coimmunoprecipitation,fluorescence polarization spectroscopy ComPPI,IntAct
PDGFRA RASA1 25348397 N/A physical interaction ComPPI
NTRK1 RASA1 14525934 25348397 8384556 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
APC RASA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
WWP2 RASA1 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAGI1 RASA1 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAV1 RASA1 15504032 20808760 24234451 25348397 association protein array,pull down,physical interaction ComPPI,IntAct
BUB1 RASA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CASP7 RASA1 10200531 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPHA2 RASA1 14525934 16051609 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PXN RASA1 25348397 N/A physical interaction,in vivo ComPPI
DNAJA3 RASA1 11116152 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XRCC6 RASA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPL RASA1 25348397 N/A physical interaction ComPPI
RAB5A RASA1 11536198 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RAP1A RASA1 14525934 2164710 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CSK RASA1 14525934 25348397 7544435 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MET RASA1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
ABI1 RASA1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
EGFR RASA1 14525934 16273093 1633149 1850098 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FGFR1 RASA1 25348397 N/A physical interaction ComPPI
RASA1 BCR 1383690 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RASA1 HSPD1 1347942 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
RASA1 CAV2 14525934 15504032 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RASA1 SPSB1 14525934 15713673 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RASA1 AFAP1L2 14525934 17412687 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RASA1 HCK 14525934 25348397 7782336 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RASA1 HTT 14525934 25348397 9079622 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RASA1 INSR 1331107 14525934 24234451 25348397 9593725 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RASA1 PTPRC 25348397 N/A in vitro,in vivo ComPPI
RASA1 CSF1R 14525934 2172781 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RASA1 EPHB3 14525934 25348397 9674711 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RASA1 BIRC5 11976319 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RASA1 AURKB 11976319 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
RASA1 DOK2 10428862 10508618 10799545 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RASA1 DOK4 12730241 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RASA1 PLCG1 24234451 25348397 9020117 physical association pull down,physical interaction ComPPI,IntAct
RASA1 ARHGAP35 25348397 N/A physical interaction ComPPI
RASA1 ANXA6 10571081 14525934 25348397 27898060 8798684 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
RASA1 G3BP1 14525934 25348397 27898060 9632780 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
RASA1 TRMT2A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASA1 BBS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASA1 ZNF579 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASA1 SERPINA4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASA1 EIF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RASA1 APP 25348397 N/A physical interaction ComPPI
RASA1 ERBB3 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
RASA1 ABL1 1383690 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RASA1 OLIG1 25348397 N/A physical interaction ComPPI
RASA1 TERF2IP 24234451 25348397 25531777 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RASA1 TSC1 17355907 24234451 25348397 physical association two hybrid ComPPI,IntAct
RASA1 DLC1 19151751 24234451 24412244 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,two hybrid array ComPPI,IntAct,OmniPath
RASA1 ATF7 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
RASA1 FYB1 22074159 24234451 25348397 association pull down ComPPI,IntAct
RASA1 AURKA 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 BMPR1A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 CDKN2A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 NRAS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 PMS2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 PTPRJ 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RASA1 STK11 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BCL10 RASA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CAPNS1 RASA1 18761085 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,competition binding ComPPI,IntAct,OmniPath
IGF1R RASA1 14525934 24234451 25348397 7642582 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RASA1 RASA1 11976319 14525934 N/A experimental interaction detection,two hybrid HPRD
STAU1 RASA1 14525934 15121898 N/A experimental interaction detection HPRD
CALPC RASA1 18761085 24234451 physical association two hybrid IntAct
RASA1 FLT3 24234451 28086240 N/A protein array IntAct
SRC RASA1 1138973 11389730 1717825 27898060 inhibition,stimulant N/A OmniPath
LCK RASA1 11389730 1850098 27898060 stimulant N/A OmniPath
PRKCB RASA1 1850098 27898060 N/A N/A OmniPath
EGFR RASA1 1385407 16273093 1633149 1850098 27898060 8647858 N/A N/A OmniPath
SOCS3 RASA1 11331873 27898060 stimulant N/A OmniPath
PDGFRB RASA1 10697503 11896619 1189662 1314164 1375321 27898060 7486683 8382774 stimulant N/A OmniPath
RASA1 HRAS 10394594 11389730 27898060 2833817 7628625 8663024 9219684 inhibition,stimulant N/A OmniPath
SOCS1 RASA1 18556463 27898060 N/A N/A OmniPath
IGF1R RASA1 27898060 7642582 stimulant N/A OmniPath
APP RASA1 21832049 27898060 N/A N/A OmniPath
RASA1 APP 21832049 27898060 N/A N/A OmniPath
EPHB2 RASA1 10644995 27898060 9233798 stimulant N/A OmniPath
RASA1 TSC1 17355907 27898060 N/A N/A OmniPath
TSC1 RASA1 17355907 27898060 N/A N/A OmniPath
RASA1 CAV2 12091389 1550403 15504032 27898060 stimulant N/A OmniPath

Visualization










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