Gene Information gene info

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GENE：ATG13

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG13
FullNmae autophagy related 13
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29091
EnsembleID ENSG00000175224
Uniprot O75143

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG13 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG13 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG13 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATG13 GO:0000045,GO:0000045,GO:0000407,GO:0000407,GO:0000407,GO:0000423,GO:0005515,GO:0005737,GO:0005739,GO:0005789,GO:0005829,GO:0005829,GO:0008285,GO:0010508,GO:0010508,GO:0019901,GO:0019901,GO:0034045,GO:0034497,GO:0034727,GO:0043539,GO:0098780,GO:1903059,GO:1903955,GO:1990316,GO:1990316

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG13 hsa:9776 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG13 hsa:9776 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ATG13 hsa:9776 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
ATG13 hsa:9776 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATG13 hsa:9776 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ATG13 hsa:9776 path:hsa05016 Huntington disease - Homo sapiens (human)
ATG13 hsa:9776 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATG13 hsa:9776 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RPTOR ATG13 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
MLST8 ATG13 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
MTOR ATG13 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
RAC1 ATG13 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26192618 27331412 28216025 interaction type N/A ACSN
ULK1 ATG13 19211835 19225151 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ATG13 MTOR 19211835 19225151 23180781 phosphorylation reaction in-gel kinase assay InnateDB
ATG13 ULK1 19225151 19287211 20562859 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,in-gel kinase assay InnateDB
RB1CC1 ATG13 19225151 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ATG101 ATG13 19287211 19597335 20562859 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ULK2 ATG13 19225151 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,in-gel kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR ATG13 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ATG13 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ATG13 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004AC389 ATG13 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075BDA4 ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004D84DB ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC ATG13 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ULK1 ATG13 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
WASHC3 ATG13 25348397 N/A physical interaction ComPPI
GABARAPL2 ATG13 20562859 21900206 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
MAP1LC3B ATG13 20562859 24234451 24290141 25348397 association,physical association pull down,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
TAB3 ATG13 25348397 N/A physical interaction ComPPI
UBC ATG13 25348397 N/A physical interaction ComPPI
HNRNPL ATG13 25348397 N/A physical interaction ComPPI
GABARAP ATG13 20562859 24234451 24290141 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
MAP1LC3A ATG13 25348397 N/A two hybrid,pull down,physical interaction,physical interaction,surface plasmon resonance array ComPPI
TAB2 ATG13 25348397 N/A physical interaction ComPPI
RB1CC1 ATG13 19597335 20562859 23392225 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
ULK1 ATG13 19597335 20562859 23392225 23524951 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
ULK2 ATG13 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ATG16L1 ATG13 23392225 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
SESN2 ATG13 24234451 25040165 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TBC1D5 ATG13 24234451 24603492 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GABARAPL1 ATG13 20562859 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MUL1 ATG13 25348397 N/A physical interaction ComPPI
PCGF1 ATG13 25348397 N/A physical interaction ComPPI
DENR ATG13 25348397 N/A physical interaction ComPPI
AMBRA1 ATG13 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
APP ATG13 25348397 N/A physical interaction ComPPI
ATG5 ATG13 23392225 24234451 25348397 association cross-linking study ComPPI,IntAct
MAP1LC3C ATG13 20562859 24234451 24290141 25348397 association,physical association two hybrid,pull down,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
ATG13 FAM221B 25348397 N/A physical interaction ComPPI
ATG13 TBC1D14 22613832 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
ATG101 ATG13 19597335 20562859 23392225 24234451 24290141 25348397 26299944 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cross-linking study,molecular sieving,pull down,x-ray crystallography,physical interaction,ion exchange chromatography ComPPI,IntAct
ATG13 ATG13 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
ATG13 ULK1 18936157 19211835 19225151 19258318 19287211 19597335 20562859 21460630 23524951 25126726 25686248 26018823 27898060 stimulant N/A OmniPath
ULK1 ATG13 18936157 19211835 19225151 19258318 19287211 19597335 20562859 21460630 21855797 23524951 25126726 25686248 26018823 26138443 27898060 stimulant N/A OmniPath
ATG101 ATG13 19287211 19597335 20562859 24100292 24290141 26299944 27898060 stimulant N/A OmniPath
ATG13 RB1CC1 19211835 19225151 19597335 20562859 27898060 stimulant N/A OmniPath
ATG13 ULK2 18936157 19225151 27898060 stimulant N/A OmniPath
ULK2 ATG13 18936157 19225151 20562859 27898060 stimulant N/A OmniPath
MTOR ATG13 19211835 19211837 19225151 19258318 27898060 inhibition N/A OmniPath

Visualization










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