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GENE：ATG16L1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG16L1
FullNmae autophagy related 16 like 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21498
EnsembleID ENSG00000085978
Uniprot Q676U5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG16L1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG16L1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATG16L1 GO:0000045,GO:0000045,GO:0000045,GO:0000045,GO:0000421,GO:0000421,GO:0005515,GO:0005776,GO:0005829,GO:0005930,GO:0006501,GO:0010508,GO:0015031,GO:0016236,GO:0016236,GO:0016236,GO:0016237,GO:0019787,GO:0021766,GO:0022038,GO:0034045,GO:0034274,GO:0034274,GO:0034497,GO:0036020,GO:0039689,GO:0042802,GO:0043495,GO:0051020,GO:0051607,GO:0097225,GO:0098792,GO:0120095

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG16L1 hsa:55054 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG16L1 hsa:55054 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ATG16L1 hsa:55054 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
ATG16L1 hsa:55054 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOD1 ATG16L1 19898471 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 ATG16L1 19898471 23180781 physical association anti tag coimmunoprecipitation InnateDB
WDFY3 ATG16L1 20417604 23180781 physical association anti tag coimmunoprecipitation InnateDB
CLTC ATG16L1 20639872 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG16L1 ATG12 20639872 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG16L1 ATG5 20639872 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB
TECPR1 ATG16L1 21575909 23180781 physical association anti tag coimmunoprecipitation InnateDB
TUFM ATG16L1 22749352 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS ATG16L1 22749352 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG ATG16L1 14743216 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP ATG16L1 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ATG16L1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ATG16L1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C ATG16L1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ATG16L1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ATG16L1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000083D87 ATG16L1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 ATG16L1 22473208 24036151 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 ATG16L1 22473208 24036151 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00002075FA ATG16L1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 ATG16L1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F ATG16L1 22473208 25416803 26165754 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002B3783 ATG16L1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ATG16L1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA ATG16L1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHUK ATG16L1 22135298 phosphorylation N/A PhosphoSite
ATG3 ATG16L1 25361965 interaction type N/A PTMCode2
ATG16L1 ATG3 25361965 interaction type N/A PTMCode2
ATG5 ATG16L1 25361965 interaction type N/A PTMCode2
ATG16L1 ATG5 25361965 interaction type N/A PTMCode2
GABARAPL2 ATG16L1 25361965 interaction type N/A PTMCode2
ATG16L1 GABARAPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RAB33A ATG16L1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC3 ATG16L1 25348397 N/A physical interaction ComPPI
GABARAPL2 ATG16L1 20562859 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
OPTN ATG16L1 25348397 N/A physical interaction ComPPI
MAP1LC3B ATG16L1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CASP3 ATG16L1 24234451 24553140 25348397 protein cleavage protease assay ComPPI,IntAct
UBC ATG16L1 25348397 N/A physical interaction ComPPI
CASP1 ATG16L1 24234451 24553140 25348397 protein cleavage protease assay ComPPI,IntAct
CASP6 ATG16L1 24234451 24553140 25348397 protein cleavage protease assay ComPPI,IntAct
XPO1 ATG16L1 25348397 N/A physical interaction ComPPI
TRIP11 ATG16L1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLTC ATG16L1 25348397 N/A physical interaction ComPPI
DVL2 ATG16L1 25348397 N/A physical interaction ComPPI
HTT ATG16L1 20417604 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CCT7 ATG16L1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA4 ATG16L1 25348397 N/A physical interaction ComPPI
GABARAP ATG16L1 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
SCOC ATG16L1 25348397 N/A physical interaction ComPPI
TLR2 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
TNK2 ATG16L1 25348397 N/A physical interaction ComPPI
MEFV ATG16L1 25348397 N/A physical interaction ComPPI
RAB3D ATG16L1 25348397 N/A physical interaction ComPPI
BECN1 ATG16L1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SNAPC4 ATG16L1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2M1 ATG16L1 25348397 N/A physical interaction ComPPI
PMF1 ATG16L1 25348397 N/A physical interaction ComPPI
FCGRT ATG16L1 25348397 N/A physical interaction ComPPI
NOD1 ATG16L1 25348397 N/A physical interaction ComPPI
ELAVL1 ATG16L1 25348397 N/A physical interaction ComPPI
RB1CC1 ATG16L1 20562859 23262492 23392225 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
DEDD2 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
TRAF3IP3 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
ULK1 ATG16L1 23392225 24234451 25348397 colocalization,association cross-linking study,physical interaction,fluorescence microscopy ComPPI,IntAct
RAB33B ATG16L1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AGPS ATG16L1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOD2 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
ATG3 ATG16L1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPC25 ATG16L1 25348397 N/A physical interaction ComPPI
ATG12 ATG16L1 17353931 20562859 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG16L1 IKBKG 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
ATG16L1 GAN 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG16L1 ATG5 12665549 14525934 20562859 23202584 23392225 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,ion exchange chromatography,two hybrid ComPPI,HPRD,IntAct
ATG16L1 CCT2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG16L1 CCT3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG16L1 MAP1LC3C 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ATG16L1 RAB35 25348397 N/A physical interaction ComPPI
ATG16L1 WDFY3 25348397 N/A physical interaction ComPPI
ATG16L1 APP 25348397 N/A physical interaction ComPPI
ATG16L1 SYNPO2 25348397 N/A physical interaction ComPPI
ATG16L1 ATG13 23392225 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ATG16L1 TMEM59 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
ATG16L1 WIPI2 25348397 N/A physical interaction ComPPI
ATG16L1 MOV10 25348397 N/A physical interaction ComPPI
ATG16L1 NXF1 25348397 N/A physical interaction ComPPI
ATG16L1 IRGM 25348397 N/A physical interaction ComPPI
ATG16L1 IKBIP 25348397 N/A physical interaction ComPPI
ATG16L1 COLEC12 25348397 N/A physical interaction ComPPI
ATG16L1 TRIM16 25348397 N/A physical interaction ComPPI
ATG16L1 GABARAPL1 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
ATG16L1 ATG101 23392225 24234451 25348397 association cross-linking study ComPPI,IntAct
ATG16L1 ATG16L1 12665549 14525934 20562859 23392225 24234451 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
ATG16L1 CLTC 20639872 27898060 stimulant N/A OmniPath
NOD2 ATG16L1 19898471 23376921 27898060 stimulant N/A OmniPath
MAVS ATG16L1 22749352 27898060 N/A N/A OmniPath
IKBKG ATG16L1 14743216 27898060 N/A N/A OmniPath
ATG12 ATG16L1 17353931 20562859 20639872 27898060 N/A N/A OmniPath
RB1CC1 ATG16L1 20562859 23262492 23392225 24100292 24954904 27898060 stimulant N/A OmniPath
RAB33B ATG16L1 18448665 27898060 stimulant N/A OmniPath
ATG16L1 ATG5 12665549 18448665 20562859 20639872 21575909 22342342 22863883 23202584 23262492 25484072 26344197 27898060 N/A N/A OmniPath
ATG5 ATG16L1 10406794 12665549 18448665 20562859 20639872 21575909 22342342 22863883 23202584 23262492 25484072 26344197 27898060 stimulant N/A OmniPath
NOD1 ATG16L1 19898471 23300079 27898060 stimulant N/A OmniPath
ATG16L1 CLTCL1 20639872 27898060 stimulant N/A OmniPath

Visualization










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