GENE：CHMP4C
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP4C |
| FullNmae | charged multivesicular body protein 4C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30599 |
| EnsembleID | ENSG00000164695 |
| Uniprot | Q96CF2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP4C | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4C | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP4C | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4C | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP4C | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4C | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4C | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP4C | GO:0000421,GO:0000776,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005643,GO:0005765,GO:0005771,GO:0005828,GO:0005829,GO:0005886,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0009838,GO:0009898,GO:0010824,GO:0015031,GO:0016236,GO:0030496,GO:0031468,GO:0032466,GO:0032511,GO:0032585,GO:0036258,GO:0036258,GO:0039702,GO:0039702,GO:0042803,GO:0043162,GO:0044878,GO:0046761,GO:0046761,GO:0051469,GO:0061763,GO:0061952,GO:0071985,GO:0090148,GO:0090543,GO:0090611,GO:0097352,GO:1901673,GO:1902774,GO:1904930 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP4C | hsa:92421 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP4C | hsa:92421 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AURKB | CHMP4C | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| XPO1 | CHMP4C | 25348397 | N/A | physical interaction | ComPPI |
| USP8 | CHMP4C | 17711858 19302785 24234451 25348397 | physical association | pull down,physical interaction | ComPPI,IntAct |
| TRPC4AP | CHMP4C | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| PDCD6IP | CHMP4C | 14525934 14678797 18511562 21988832 24234451 25348397 | physical association | two hybrid,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| STAMBP | CHMP4C | 17711858 24234451 25348397 | physical association | pull down,physical interaction | ComPPI,IntAct |
| VPS4A | CHMP4C | 14505570 14525934 24234451 24814515 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| USP54 | CHMP4C | 19302785 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| CHMP4A | CHMP4C | 14505570 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| CHMP4B | CHMP4C | 14505570 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP4C | CC2D1A | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP4C | CCDC12 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4C | BROX | 22484091 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP4C | ZFYVE19 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| CHMP4C | IGHA1 | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CHMP4C | CHMP7 | 16856878 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP1B | CHMP4C | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4C | CHMP4C | 14505570 14525934 | N/A | two hybrid | HPRD |
| AURKB | CHMP4C | 22422861 22724069 27898060 | stimulant | N/A | OmniPath |
| TP53 | CHMP4C | 18431400 27898060 | stimulant | N/A | OmniPath |