GENE：CHMP7
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP7 |
| FullNmae | charged multivesicular body protein 7 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:28439 |
| EnsembleID | ENSG00000147457 |
| Uniprot | Q8WUX9 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP7 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP7 | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP7 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP7 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP7 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP7 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP7 | GO:0000421,GO:0000776,GO:0000785,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005765,GO:0005771,GO:0005828,GO:0005829,GO:0005829,GO:0005886,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0009898,GO:0010458,GO:0015031,GO:0030496,GO:0031468,GO:0031468,GO:0032511,GO:0032585,GO:0036258,GO:0039702,GO:0039702,GO:0043162,GO:0045324,GO:0046761,GO:0051469,GO:0061763,GO:0061952,GO:0071168,GO:0071985,GO:0090148,GO:0097352,GO:1901673,GO:1902774,GO:1904903,GO:1904930 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP7 | hsa:91782 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP7 | hsa:91782 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | CHMP7 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CHMP7 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | CHMP7 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | CHMP7 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CHMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CHMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CHMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CHMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CHMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | CHMP7 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000017EA6A | CHMP7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | CHMP7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000041CB9C | CHMP7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TUFM | CHMP7 | 25348397 | N/A | physical interaction | ComPPI |
| CANX | CHMP7 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| XPO1 | CHMP7 | 25348397 | N/A | physical interaction | ComPPI |
| WDR12 | CHMP7 | 25348397 | N/A | physical interaction | ComPPI |
| USP8 | CHMP7 | 25348397 | N/A | physical interaction | ComPPI |
| CREB3 | CHMP7 | 25348397 | N/A | physical interaction | ComPPI |
| PAFAH1B3 | CHMP7 | 14525934 16189514 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ARHGAP17 | CHMP7 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | CHMP7 | 16856878 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP4B | CHMP7 | 16856878 24234451 25348397 | colocalization,physical association | two hybrid,pull down,confocal microscopy | ComPPI,IntAct |
| CHMP4C | CHMP7 | 16856878 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP7 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP7 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP7 | USP14 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP7 | TCTN2 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |