GENE:DYNC1I2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DYNC1I2 |
| FullNmae | dynein cytoplasmic 1 intermediate chain 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2964 |
| EnsembleID | ENSG00000077380 |
| Uniprot | Q13409 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DYNC1I2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DYNC1I2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DYNC1I2 | GO:0003777,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0007018,GO:0010970,GO:0030286,GO:0031982,GO:0045503,GO:0045504 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DYNC1I2 | hsa:1781 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| DYNC1I2 | hsa:1781 | path:hsa04814 | Motor proteins - Homo sapiens (human) |
| DYNC1I2 | hsa:1781 | path:hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
| DYNC1I2 | hsa:1781 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | DYNC1I2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | DYNC1I2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | DYNC1I2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | DYNC1I2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | DYNC1I2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | DYNC1I2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPRE1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| EIF3G | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNLL1 | DYNC1I2 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKAR2B | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| VCP | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS26 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK3 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| JUN | DYNC1I2 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ITK | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| CUL3 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1LI1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| UBC | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| YBX1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNLT3 | DYNC1I2 | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| XRCC5 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| PSMA5 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| MAP2 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| AKAP12 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DCTN1 | DYNC1I2 | 14525934 24234451 25348397 26638075 8522607 | association | experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification | ComPPI,HPRD,IntAct |
| ADD3 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| PSMD8 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| ECT2 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| PAFAH1B1 | DYNC1I2 | 24234451 25348397 27173435 | association,physical association | physical interaction,tandem affinity purification,inference by socio-affinity scoring | ComPPI,IntAct |
| PSMC5 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS13 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| TUBGCP3 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1H1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| PEX14 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DDX1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNLT1 | DYNC1I2 | 24234451 25348397 27173435 | association,physical association | physical interaction,tandem affinity purification,inference by socio-affinity scoring | ComPPI,IntAct |
| CCAR1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| BRCA1 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| NIN | DYNC1I2 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| EIF3A | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| EIF3B | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| PNN | DYNC1I2 | 25348397 | N/A | two hybrid | ComPPI |
| SRRM2 | DYNC1I2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | ABCF1 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | DYNLRB1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| DYNC1I2 | HNRNPA0 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | SERBP1 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | RPS5 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | ADD1 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | DYNLRB2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1I2 | DYNC1I1 | 25348397 | N/A | physical interaction | ComPPI |
| NPM1 | DYNC1I2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
