diseaseid	CellDeathType	Disease	pmid	Description
1	alkaliptosis	Acute myeloid leukemia	34034094	NF-κB-mediated CA9 downregulation is required for intracellular pH upregulation, thereby inducing alkaliptosis in venetoclax-resistant cells. These findings provide a new strategy to selectively remove venetoclax-resistant AML cells.
2	alkaliptosis	diabetes	37851176	The role of alkaliptosis has been preliminarily studied in tumors, diabetes and other diseases, and further studies are needed to facilitate the development of novel treatment based on alkaliptosis.
3	alkaliptosis	diabetes	37918258	However, the clear effector molecules of alkaliptosis and pathological significance of alkaliptosis in human disease including diabetes remains elusive.
4	alkaliptosis	diabetic endothelial dysfunction	37918258	Multiple subroutines covered by RCD may be involved in diabetic endothelial dysfunction, including apoptosis, autophagy, necroptosis, pyroptosis, entosis, ferroptosis, ferroautophagy, parthanatos, netotic cell death, lysosome-dependent cell death, alkaliptosis, oxeiptosis, cuproptosis, and PANoptosis.
5	alkaliptosis	Lower Grade Glioma	37543196	Most of clinical characteristics were associated with the SLC10A3 expression level. SLC10A3 with diagnostic and prognostic value (OS, DSS, and progression-free interval) was an independent prognostic factor in LGG. Moreover, Nomograms (WHO grade, 1p/19q codeletion, age and SLC10A3) had moderately accurate predictive for OS and DSS. Functional analysis showed that SLC10A3 might participate in the transport of multiple substances, neurogenic signaling, immune response, and programmed cell death in LGG. SLC10A3 correlated with immune infiltration in LGG and moderately correlated with the gene signature of pyroptosis, lysosome-dependent cell death, necroptosis, apoptosis, ferroptosis, alkaliptosis, and autophagy-dependent cell death.
6	alkaliptosis	Ovarian Cancer	38751020	Mechanistically, ATPase H+ transporting V0 subunit D1 (ATP6V0D1), a key regulator of alkaliptosis, plays a pivotal role by mediating the downregulation of ATP-binding cassette subfamily B member 1 (ABCB1), a multidrug resistance protein. Both ATP6V0D1 overexpression through gene transfection and pharmacological enhancement of ATP6V0D1 protein stability using JTC801 effectively inhibit ABCB1 upregulation, resulting in growth inhibition in drug-resistant cells. Additionally, increasing intracellular pH to alkaline (pH 8.5) via sodium hydroxide application suppresses ABCB1 expression, whereas reducing the pH to acidic conditions (pH 6.5) with hydrochloric acid amplifies ABCB1 expression in drug-resistant cells. Collectively, these results indicate a potentially effective therapeutic strategy for targeting paclitaxel-resistant ovarian cancer by inducing ATP6V0D1-dependent alkaliptosis.
7	alkaliptosis	Pancreatic cancer	37601110	Alkaliptosis, a pH-dependent cell death process triggered by the small molecular compound JTC801, has been identified as a novel approach for malignant tumor treatment, particularly in pancreatic cancer.
id	Symbol	Type	hgncid	name	locus_type	status	entrez_id	ensembl_gene_id	uniprot_ids
11200	IKBKB	alkaliptosis	HGNC:5960	inhibitor of nuclear factor kappa B kinase subunit beta	gene with protein product	Approved	3551	ENSG00000104365	O14920
11201	NFKB1	alkaliptosis	HGNC:7794	nuclear factor kappa B subunit 1	gene with protein product	Approved	4790	ENSG00000109320	P19838
11202	CA9	alkaliptosis	HGNC:1383	carbonic anhydrase 9	gene with protein product	Approved	768	ENSG00000107159	Q16790
11203	CHUK	alkaliptosis	HGNC:1974	component of inhibitor of nuclear factor kappa B kinase complex	gene with protein product	Approved	1147	ENSG00000213341	O15111
11204	IKBKG	alkaliptosis	HGNC:5961	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	gene with protein product	Approved	8517	ENSG00000269335	Q9Y6K9
11205	RELA	alkaliptosis	HGNC:9955	RELA proto-oncogene, NF-kB subunit	gene with protein product	Approved	5970	ENSG00000173039	Q04206
11206	NFKB1A	alkaliptosis	HGNC:7797	NFKB inhibitor alpha	gene with protein product	Approved	4792	ENSG00000100906	P25963
lncid	cdtype	lncRNA	lnctarget	pmid	description
129331	alkaliptosis	SNHG29	IKBKB	24297251	starBase v2.0
129332	alkaliptosis	LINC01562	IKBKB	24297251	starBase v2.0
129333	alkaliptosis	LINC00339	IKBKB	24297251	starBase v2.0
129334	alkaliptosis	AJ009632.2	IKBKB	24297251	starBase v2.0
129335	alkaliptosis	AL445235.1	IKBKB	24297251	starBase v2.0
129336	alkaliptosis	MYO16-AS1	IKBKB	24297251	starBase v2.0
129337	alkaliptosis	STX18-AS1	IKBKB	24297251	starBase v2.0
129338	alkaliptosis	AC139887.2	IKBKB	24297251	starBase v2.0
129339	alkaliptosis	MALAT1	IKBKB	24297251	starBase v2.0
129340	alkaliptosis	CASC19	IKBKB	24297251	starBase v2.0
129341	alkaliptosis	CASC19	IKBKB	24297251	starBase v2.0
129342	alkaliptosis	AC087500.1	IKBKB	24297251	starBase v2.0
129343	alkaliptosis	AC027796.4	IKBKB	24297251	starBase v2.0
129344	alkaliptosis	NEAT1	IKBKB	24297251	starBase v2.0
129345	alkaliptosis	NEAT1	IKBKB	24297251	starBase v2.0
129346	alkaliptosis	PSMA3-AS1	IKBKB	24297251	starBase v2.0
129347	alkaliptosis	AC144548.1	IKBKB	24297251	starBase v2.0
129348	alkaliptosis	AC007220.1	IKBKB	24297251	starBase v2.0
129349	alkaliptosis	AL109930.1	IKBKB	24297251	starBase v2.0
129350	alkaliptosis	MALAT1	CA9	24297251	starBase v2.0
129351	alkaliptosis	MALAT1	CA9	24297251	starBase v2.0
129352	alkaliptosis	NEAT1	CA9	24297251	starBase v2.0
129353	alkaliptosis	AC025178.1	CA9	24297251	starBase v2.0
129354	alkaliptosis	MIRLET7BHG	CHUK	24297251	starBase v2.0
129355	alkaliptosis	TPT1-AS1	CHUK	24297251	starBase v2.0
129356	alkaliptosis	XIST	CHUK	24297251	starBase v2.0
129357	alkaliptosis	XIST	CHUK	24297251	starBase v2.0
129358	alkaliptosis	AL450384.2	CHUK	24297251	starBase v2.0
129359	alkaliptosis	MALAT1	CHUK	24297251	starBase v2.0
129360	alkaliptosis	LINC00842	CHUK	24297251	starBase v2.0
129361	alkaliptosis	NIPBL-DT	CHUK	24297251	starBase v2.0
129362	alkaliptosis	FIRRE	IKBKG	24297251	starBase v2.0
129363	alkaliptosis	UBA6-AS1	IKBKG	24297251	starBase v2.0
129364	alkaliptosis	AC011603.2	IKBKG	24297251	starBase v2.0
129365	alkaliptosis	LINC01886	IKBKG	24297251	starBase v2.0
129366	alkaliptosis	MALAT1	IKBKG	24297251	starBase v2.0
129367	alkaliptosis	AC008770.3	IKBKG	24297251	starBase v2.0
129368	alkaliptosis	MIR924HG	IKBKG	24297251	starBase v2.0
129369	alkaliptosis	AL117379.1	IKBKG	24297251	starBase v2.0
129370	alkaliptosis	AL049557.1	IKBKG	24297251	starBase v2.0
129371	alkaliptosis	NEAT1	RELA	24297251	starBase v2.0
129372	alkaliptosis	NEAT1	RELA	24297251	starBase v2.0
129373	alkaliptosis	PVT1	RELA	24297251	starBase v2.0
129374	alkaliptosis	AL160006.1	RELA	24297251	starBase v2.0
129375	alkaliptosis	AC004687.1	RELA	24297251	starBase v2.0
129376	alkaliptosis	LINC00842	RELA	24297251	starBase v2.0
mirnaid	cdtype	mirna	mitarget	pmid	description
67110	alkaliptosis	hsa-miR-15a-5p	IKBKB	24297251	starBase v2.0
67111	alkaliptosis	hsa-miR-16-5p	IKBKB	24297251	starBase v2.0
67112	alkaliptosis	hsa-miR-214-3p	IKBKB	24297251	starBase v2.0
67113	alkaliptosis	hsa-miR-214-3p	IKBKB	24297251	starBase v2.0
67114	alkaliptosis	hsa-miR-15b-5p	IKBKB	24297251	starBase v2.0
67115	alkaliptosis	hsa-miR-195-5p	IKBKB	24297251	starBase v2.0
67116	alkaliptosis	hsa-miR-424-5p	IKBKB	24297251	starBase v2.0
67117	alkaliptosis	hsa-miR-497-5p	IKBKB	24297251	starBase v2.0
67118	alkaliptosis	hsa-miR-15a-5p	CHUK	24297251	starBase v2.0
67119	alkaliptosis	hsa-miR-16-5p	CHUK	24297251	starBase v2.0
67120	alkaliptosis	hsa-miR-197-3p	CHUK	24297251	starBase v2.0
67121	alkaliptosis	hsa-miR-15b-5p	CHUK	24297251	starBase v2.0
67122	alkaliptosis	hsa-miR-195-5p	CHUK	24297251	starBase v2.0
67123	alkaliptosis	hsa-miR-377-3p	CHUK	24297251	starBase v2.0
67124	alkaliptosis	hsa-miR-424-5p	CHUK	24297251	starBase v2.0
67125	alkaliptosis	hsa-miR-329-3p	CHUK	24297251	starBase v2.0
67126	alkaliptosis	hsa-miR-497-5p	CHUK	24297251	starBase v2.0
67127	alkaliptosis	hsa-miR-362-3p	CHUK	24297251	starBase v2.0
celldeathtype	datasource	pathwayname	pathwayid	intersection_num	pathwaygene_num	celldeathgenenum	genesymbols	p_value
1	alkaliptosis	KEGG	Nitrogen metabolism - Homo sapiens (human)	hsa00910	1	17	7	CA9	0.00593573712614837
2	alkaliptosis	KEGG	Antifolate resistance - Homo sapiens (human)	hsa01523	5	30	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.12021503184678e-13
3	alkaliptosis	KEGG	MAPK signaling pathway - Homo sapiens (human)	hsa04010	5	301	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.53051615825461e-08
4	alkaliptosis	KEGG	Ras signaling pathway - Homo sapiens (human)	hsa04014	5	236	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	4.51777215637605e-09
5	alkaliptosis	KEGG	cAMP signaling pathway - Homo sapiens (human)	hsa04024	2	225	7	RELA,NFKB1	0.00254939804003484
6	alkaliptosis	KEGG	Chemokine signaling pathway - Homo sapiens (human)	hsa04062	5	192	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.60029101081705e-09
7	alkaliptosis	KEGG	NF-kappa B signaling pathway - Homo sapiens (human)	hsa04064	5	104	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	7.1860073447283e-11
8	alkaliptosis	KEGG	HIF-1 signaling pathway - Homo sapiens (human)	hsa04066	2	109	7	RELA,NFKB1	0.000607124994721264
9	alkaliptosis	KEGG	FoxO signaling pathway - Homo sapiens (human)	hsa04068	2	131	7	IKBKB,CHUK	0.000875077866752338
10	alkaliptosis	KEGG	Sphingolipid signaling pathway - Homo sapiens (human)	hsa04071	2	121	7	RELA,NFKB1	0.000747350116658496
11	alkaliptosis	KEGG	Mitophagy - animal - Homo sapiens (human)	hsa04137	1	103	7	RELA	0.0355030273057549
12	alkaliptosis	KEGG	mTOR signaling pathway - Homo sapiens (human)	hsa04150	2	156	7	IKBKB,CHUK	0.00123729776746206
13	alkaliptosis	KEGG	PI3K-Akt signaling pathway - Homo sapiens (human)	hsa04151	5	359	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.69575064995686e-08
14	alkaliptosis	KEGG	Apoptosis - Homo sapiens (human)	hsa04210	5	136	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.8050117784062e-10
15	alkaliptosis	KEGG	Longevity regulating pathway - Homo sapiens (human)	hsa04211	2	89	7	RELA,NFKB1	0.000405275892170098
16	alkaliptosis	KEGG	Cellular senescence - Homo sapiens (human)	hsa04218	2	156	7	RELA,NFKB1	0.00123729776746206
17	alkaliptosis	KEGG	Osteoclast differentiation - Homo sapiens (human)	hsa04380	5	135	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.70211186759184e-10
18	alkaliptosis	KEGG	Neutrophil extracellular trap formation - Homo sapiens (human)	hsa04613	2	191	7	RELA,NFKB1	0.00184613682659562
19	alkaliptosis	KEGG	Toll-like receptor signaling pathway - Homo sapiens (human)	hsa04620	5	108	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	8.70734595537215e-11
20	alkaliptosis	KEGG	NOD-like receptor signaling pathway - Homo sapiens (human)	hsa04621	5	186	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.36375055692639e-09
21	alkaliptosis	KEGG	RIG-I-like receptor signaling pathway - Homo sapiens (human)	hsa04622	5	71	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.0201950395583e-11
22	alkaliptosis	KEGG	Cytosolic DNA-sensing pathway - Homo sapiens (human)	hsa04623	5	75	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.35194078154655e-11
23	alkaliptosis	KEGG	C-type lectin receptor signaling pathway - Homo sapiens (human)	hsa04625	5	104	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	7.1860073447283e-11
24	alkaliptosis	KEGG	IL-17 signaling pathway - Homo sapiens (human)	hsa04657	5	94	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	4.29281055147612e-11
25	alkaliptosis	KEGG	Th1 and Th2 cell differentiation - Homo sapiens (human)	hsa04658	5	92	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.84658971341878e-11
26	alkaliptosis	KEGG	Th17 cell differentiation - Homo sapiens (human)	hsa04659	5	108	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	8.70734595537215e-11
27	alkaliptosis	KEGG	T cell receptor signaling pathway - Homo sapiens (human)	hsa04660	5	121	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.55116808286948e-10
28	alkaliptosis	KEGG	B cell receptor signaling pathway - Homo sapiens (human)	hsa04662	5	84	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.41640041309665e-11
29	alkaliptosis	KEGG	TNF signaling pathway - Homo sapiens (human)	hsa04668	5	114	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.14616982571647e-10
30	alkaliptosis	KEGG	Neurotrophin signaling pathway - Homo sapiens (human)	hsa04722	3	119	7	RELA,NFKB1,IKBKB	7.06458334320814e-06
31	alkaliptosis	KEGG	Insulin signaling pathway - Homo sapiens (human)	hsa04910	1	137	7	IKBKB	0.0469827038056686
32	alkaliptosis	KEGG	Prolactin signaling pathway - Homo sapiens (human)	hsa04917	2	70	7	RELA,NFKB1	0.000250727805593653
33	alkaliptosis	KEGG	Adipocytokine signaling pathway - Homo sapiens (human)	hsa04920	5	69	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	8.80762129895629e-12
34	alkaliptosis	KEGG	Relaxin signaling pathway - Homo sapiens (human)	hsa04926	2	129	7	RELA,NFKB1	0.000848744218021391
35	alkaliptosis	KEGG	Type II diabetes mellitus - Homo sapiens (human)	hsa04930	1	46	7	IKBKB	0.0159917172448576
36	alkaliptosis	KEGG	Insulin resistance - Homo sapiens (human)	hsa04931	3	108	7	RELA,NFKB1,IKBKB	5.27599333366435e-06
37	alkaliptosis	KEGG	Non-alcoholic fatty liver disease - Homo sapiens (human)	hsa04932	3	155	7	RELA,NFKB1,IKBKB	1.56192593920856e-05
38	alkaliptosis	KEGG	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)	hsa04933	2	100	7	RELA,NFKB1	0.000511347006283858
39	alkaliptosis	KEGG	Alcoholic liver disease - Homo sapiens (human)	hsa04936	5	142	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.49013706824053e-10
40	alkaliptosis	KEGG	Alzheimer disease - Homo sapiens (human)	hsa05010	5	384	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	5.17323137660952e-08
41	alkaliptosis	KEGG	Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)	hsa05022	2	476	7	RELA,NFKB1	0.0109656075216047
42	alkaliptosis	KEGG	Cocaine addiction - Homo sapiens (human)	hsa05030	2	49	7	RELA,NFKB1	0.000122522101246858
43	alkaliptosis	KEGG	Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)	hsa05120	5	70	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	9.48430223246532e-12
44	alkaliptosis	KEGG	Pathogenic Escherichia coli infection - Homo sapiens (human)	hsa05130	5	198	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.8685127889384e-09
45	alkaliptosis	KEGG	Shigellosis - Homo sapiens (human)	hsa05131	5	247	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	5.67906555115627e-09
46	alkaliptosis	KEGG	Salmonella infection - Homo sapiens (human)	hsa05132	5	249	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	5.91369186953017e-09
47	alkaliptosis	KEGG	Pertussis - Homo sapiens (human)	hsa05133	2	76	7	RELA,NFKB1	0.000295593814351847
48	alkaliptosis	KEGG	Legionellosis - Homo sapiens (human)	hsa05134	2	56	7	RELA,NFKB1	0.000160258341611375
49	alkaliptosis	KEGG	Yersinia infection - Homo sapiens (human)	hsa05135	5	137	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.91101809324346e-10
50	alkaliptosis	KEGG	Leishmaniasis - Homo sapiens (human)	hsa05140	2	77	7	RELA,NFKB1	0.000303425669446522
51	alkaliptosis	KEGG	Chagas disease - Homo sapiens (human)	hsa05142	5	102	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	6.50954845582419e-11
52	alkaliptosis	KEGG	Toxoplasmosis - Homo sapiens (human)	hsa05145	5	111	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.00089936339032e-10
53	alkaliptosis	KEGG	Amoebiasis - Homo sapiens (human)	hsa05146	2	102	7	RELA,NFKB1	0.000531933130726747
54	alkaliptosis	KEGG	Tuberculosis - Homo sapiens (human)	hsa05152	2	180	7	RELA,NFKB1	0.00164210610289639
55	alkaliptosis	KEGG	Hepatitis C - Homo sapiens (human)	hsa05160	5	158	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	5.98775806714968e-10
56	alkaliptosis	KEGG	Hepatitis B - Homo sapiens (human)	hsa05161	5	162	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	6.79359901667453e-10
57	alkaliptosis	KEGG	Measles - Homo sapiens (human)	hsa05162	5	138	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.02020186637719e-10
58	alkaliptosis	KEGG	Human cytomegalovirus infection - Homo sapiens (human)	hsa05163	5	225	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.55440765709147e-09
59	alkaliptosis	KEGG	Influenza A - Homo sapiens (human)	hsa05164	5	171	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	8.92512508343657e-10
60	alkaliptosis	KEGG	Human papillomavirus infection - Homo sapiens (human)	hsa05165	5	331	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.46244091783865e-08
61	alkaliptosis	KEGG	Human T-cell leukemia virus 1 infection - Homo sapiens (human)	hsa05166	5	222	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.32249761036962e-09
62	alkaliptosis	KEGG	Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	hsa05167	5	194	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.68603042638438e-09
63	alkaliptosis	KEGG	Herpes simplex virus 1 infection - Homo sapiens (human)	hsa05168	5	512	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.17062189777906e-07
64	alkaliptosis	KEGG	Epstein-Barr virus infection - Homo sapiens (human)	hsa05169	5	202	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.06643613331892e-09
65	alkaliptosis	KEGG	Human immunodeficiency virus 1 infection - Homo sapiens (human)	hsa05170	5	212	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.63516930498753e-09
66	alkaliptosis	KEGG	Coronavirus disease - COVID-19 - Homo sapiens (human)	hsa05171	5	232	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	4.14599710119035e-09
67	alkaliptosis	KEGG	Pathways in cancer - Homo sapiens (human)	hsa05200	5	531	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.60201471702359e-07
68	alkaliptosis	KEGG	Transcriptional misregulation in cancer - Homo sapiens (human)	hsa05202	2	193	7	RELA,NFKB1	0.00188447426239913
69	alkaliptosis	KEGG	Viral carcinogenesis - Homo sapiens (human)	hsa05203	3	204	7	RELA,IKBKG,NFKB1	3.55127635272012e-05
70	alkaliptosis	KEGG	MicroRNAs in cancer - Homo sapiens (human)	hsa05206	2	310	7	NFKB1,IKBKB	0.00477690713479229
71	alkaliptosis	KEGG	Chemical carcinogenesis - receptor activation - Homo sapiens (human)	hsa05207	2	212	7	RELA,NFKB1	0.00226761816195675
72	alkaliptosis	KEGG	Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)	hsa05208	5	223	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.39841599306112e-09
73	alkaliptosis	KEGG	Pancreatic cancer - Homo sapiens (human)	hsa05212	5	76	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.44702028137544e-11
74	alkaliptosis	KEGG	Prostate cancer - Homo sapiens (human)	hsa05215	5	97	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	5.0388027084125e-11
75	alkaliptosis	KEGG	Chronic myeloid leukemia - Homo sapiens (human)	hsa05220	5	76	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	1.44702028137544e-11
76	alkaliptosis	KEGG	Acute myeloid leukemia - Homo sapiens (human)	hsa05221	5	67	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	7.56994467110417e-12
77	alkaliptosis	KEGG	Small cell lung cancer - Homo sapiens (human)	hsa05222	5	92	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.84658971341878e-11
78	alkaliptosis	KEGG	PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)	hsa05235	5	89	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.2475022671008e-11
79	alkaliptosis	KEGG	Inflammatory bowel disease - Homo sapiens (human)	hsa05321	2	65	7	RELA,NFKB1	0.000216128017106465
80	alkaliptosis	KEGG	Primary immunodeficiency - Homo sapiens (human)	hsa05340	1	38	7	IKBKG	0.0132264024000365
81	alkaliptosis	KEGG	Diabetic cardiomyopathy - Homo sapiens (human)	hsa05415	2	203	7	RELA,NFKB1	0.00208186605875227
82	alkaliptosis	KEGG	Lipid and atherosclerosis - Homo sapiens (human)	hsa05417	5	215	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	2.82814660579334e-09
83	alkaliptosis	KEGG	Fluid shear stress and atherosclerosis - Homo sapiens (human)	hsa05418	5	139	7	IKBKG,NFKB1,RELA,IKBKB,CHUK	3.13263193163493e-10
substance_id	chemicals	cdtype	type	pmid	description
1	small molecule compound JTC801 	alkaliptosis	inducer	35217834 	The small molecule compound JTC801 is identified as having strong cancer cell-killing effects.
2	CA9	alkaliptosis	inducer	35217834 	CA9 catalyzes the reversible hydration of carbon dioxide and is overexpressed in many types of solid cancer, including clear cell renal cell carcinoma and PDAC, where it promotes tumor growth by maintaining acidosis.
3	ammonia	alkaliptosis	inducer	37612413 	Alkaliptosis is a recently discovered form of regulated necrosis triggered by exposure to alkaline agents, such as ammonia, sodium hydroxide, or high-pH buffers.
4	odium hydroxide	alkaliptosis	inducer	37612413 	Alkaliptosis is a recently discovered form of regulated necrosis triggered by exposure to alkaline agents, such as ammonia, sodium hydroxide, or high-pH buffers.
5	high-pH buffers	alkaliptosis	inducer	37612413 	Alkaliptosis is a recently discovered form of regulated necrosis triggered by exposure to alkaline agents, such as ammonia, sodium hydroxide, or high-pH buffers.
6	nuclear factor-kappa B (NF-κB)	alkaliptosis	inducer	37612413 	NF-κB negatively regulates CA9 activity, which in turn inhibits alkaliptosis29. Depletion of CA9 can restored the sensitivity of cancer cells that lack functional NF-κB to alkaliptosis
7	 carbonic anhydrase 9	alkaliptosis	inducer	37612413 	CA9 is a member of the carbonic anhydrase family that plays a role in regulating pH levels
8	JTC801 	alkaliptosis	inducer	35321239 	JTC801 has selective toxicity to cancer cells and no selective toxicity to normal cells. 
9	RELA	alkaliptosis	inducer	35321239 	Inhibition of IKBKB (kappa B kinase subunit B) or RELA by using drugs or controlling gene expression can reduce JTC801 to effectively kill human pancreas, kidney, prostate, skin and brain cancer cells through alkaliptosis
10	IKBKB	alkaliptosis	inducer	35321239 	Inhibition of IKBKB (kappa B kinase subunit B) or RELA by using drugs or controlling gene expression can reduce JTC801 to effectively kill human pancreas, kidney, prostate, skin and brain cancer cells through alkaliptosis
11	JTC801 	alkaliptosis	inducer	32411446	 Song et al. showed that JTC801 can induce a pH-dependent cell death in human pancreatic cancer cells by activating NF-κB
12	NF-κB	alkaliptosis	inducer	32411446	Although NF-κB inhibitors can inhibit alkaliptosis [29], no effect of Nrf2 knockout alters JTC801-induced cell death 
13	Nrf2	alkaliptosis	inducer	32411446	Although NF-κB inhibitors can inhibit alkaliptosis [29], no effect of Nrf2 knockout alters JTC801-induced cell death 
14	JTC801	alkaliptosis	inducer	37918258	JTC801, a selective antagonist of opioid-related nociceptin receptor 1, induces alkaliptosis through activation of the NF-κB-pathway mediated intracellular alkalinization and reduction of the pH regulator carbonic anhydrase 9
15	NF-κB-pathway	alkaliptosis	inducer	37918258	JTC801, a selective antagonist of opioid-related nociceptin receptor 1, induces alkaliptosis through activation of the NF-κB-pathway mediated intracellular alkalinization and reduction of the pH regulator carbonic anhydrase 9
16	CA9 downregulation 	alkaliptosis	inducer	37918258 	Alkaliptosis is caused by CA9 downregulation and subsequent intracellular pH upregulation in cancer cells. 
17	V-ATPase subunit d1 and STAT3	alkaliptosis	inducer	37918258 	 Increased interaction between V-ATPase subunit d1 and STAT3 promotes JTC801-induced alkaliptosis. 
18	ATP6V0D1	alkaliptosis	inducer	35504950	These findings establish the pro-death effect of ATP6V0D1 in alkaliptosis and may help researchers develop non-apoptotic cell death strategies for tumor treatment.++
19	JTC801	alkaliptosis	inducer	37851176	JTC801 that specifically induced pH-dependent death in cancer cells and slowed tumor growth in mice 
20	JTC801	alkaliptosis	inducer	36369365	The small-molecule compound JTC801 inhibits venetoclax-resistant acute myeloid leukemia by targeting NF-κB to induce 
21	N-acetyl alanine	alkaliptosis	inhibitor	37918258	In contrast, acidic conditions such as N-acetyl alanine, N-acetyl cysteine, and acidic medium can be used to block JTC801-induced alkaliptosis by inhibiting intracellular alkalization
22	N-acetyl cysteine	alkaliptosis	inhibitor	37918258	In contrast, acidic conditions such as N-acetyl alanine, N-acetyl cysteine, and acidic medium can be used to block JTC801-induced alkaliptosis by inhibiting intracellular alkalization
23	acidic medium	alkaliptosis	inhibitor	37918258	In contrast, acidic conditions such as N-acetyl alanine, N-acetyl cysteine, and acidic medium can be used to block JTC801-induced alkaliptosis by inhibiting intracellular alkalization
24	carrier	alkaliptosis	other	36395954	Through copper depletion, glutathione (GSH) blocks the cuproptosis process, rescues the activation of glutamine transporters, and prevents the loss of Fe-S cluster proteins, except for protecting cancer cells from apoptosis, protein degradation and oxidative damage. In addition, the copper ionophore curcumin can control the metabolisms of lipids, RNA, NADH and NADPH in colorectal cancer cells, and also up-regulates positive cuproptosis mediators. This work not only established the crosstalk between copper stress and cuproptosis, but also discolored the suppression and acceleration of cuproptosis by GSH and curcumin, respectively. Our results are significant for understanding cuproptosis process and developing novel anticancer reagents based on cuproptosis.
25	Arenobufagin	alkaliptosis	other	37920505	ArBu synergizes with CDDP to inhibit tumor growth both in vivo and in vitro by inducing alkaliptosis. This indicated that ArBu combined with CDDP may serve as a potential agent for the treatment of gastric cancer.