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Cite Us: Chen C, Zhou D, Gu Y, Wang C, Zhang M, Lin X, Xing J, Wang H, et al. SEA version 3.0: a comprehensive extension and update of the Super-Enhancer archive [J]. Nucleic acids research. 2019, pii: gkz1028.
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Data Growth Rate / Summary


SEA version 3.0 (i) stores the newly predicted super-enhancers and enhancers of 11 species based on a more optimized rules, expands the types of Cell/Tissue/Disease from 134 to 246, extends the SEs ranking factors from 1 to 3 and the number of species would be increased when the needed data emerge; (ii) includes experimentally identified and confirmed super-enhancers; (iii) lists the functional compositional organization for each SEs through Hi-C data based peak calling; (iv) provides the cell-type/tissue/disease specificity of super-enhancer with an quantitative entropy value; (v) includes online regulatory network supporting flexible analysis of the relationships among coding / non-coding genes and super-enhancer; (vi) supplements classification of publications related to super-enhancers which should be useful for biologist following advance of super-enhancer research; (vii) updated the visualization tool “Browser View of Super-Enhancers”, which is contained of abundant annotation tracks with supporting customized views in genomic scale; (viii) integrates Enrichr into SEA version 3.0 to process the functional significance analysis of these super enhancers.

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